Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9595142 | 0.91 | LMNA (0.55) | LMNADHODHALDH1A1KDM4EMAPT | |
| SCHEMBL31500251 | 0.89 | MAOA (0.52) | POLBNR4A2MPOALDH1A1KDM4E | |
| SCHEMBL9593290 | 0.87 | LMNA (0.62) | LMNADHODHMEN1KMT2AALDH1A1 | |
| SCHEMBL12047873 | 0.86 | LMNA (0.50) | LMNAPOLBHSP90AB1NR4A2DHODH | |
| SCHEMBL20008613 | 0.83 | NR4A2 (0.53) | LMNAPOLBHSP90AB1NR4A2KMT2A | |
| SCHEMBL9595057 | 0.83 | NQO2 (0.50) | LMNAPOLBNR4A2DHODHKMT2A | |
| SCHEMBL17423119 | 0.83 | POLB (0.55) | POLBNR4A2KMT2AMPOALDH1A1 | |
| SCHEMBL31500224 | 0.83 | MAOA (0.58) | LMNANR4A2MPOALDH1A1KDM4E | |
| SCHEMBL9593843 | 0.82 | LMNA (0.53) | LMNADHODHMEN1KMT2AALDH1A1 | |
| SCHEMBL27961718 | 0.82 | MAOA (0.67) | LMNAMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020248075-A9 | TARGETING DNA REPAIR IN TUMOR CELLS VIA INHIBITION OF ERCC1-XPF | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2021-10-21 | — | — | WO | disclosed |
| WO-2020248075-A1 | TARGETING DNA REPAIR IN TUMOR CELLS VIA INHIBITION OF ERCC1-XPF | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2020-12-17 | — | — | WO | disclosed |