Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.57 |
| ▸ | HTR3B | O95264 | 5/20 | 0.57 |
| ▸ | HTR3A | P46098 | 5/20 | 0.57 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.57 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 4/20 | 0.55 |
| ▸ | HTR1A | P08908 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22796404 | 0.86 | HTR3E (0.56) | TP53LMNAMAPTHTR3EHTR3B | |
| SCHEMBL8565555 | 0.82 | HTR3E (0.67) | TP53LMNAMAPTTHRBHTR3E | |
| SCHEMBL8563501 | 0.76 | LMNA (0.56) | TP53LMNAMAPTTHRBHTR3E | |
| SCHEMBL8567429 | 0.76 | HTR3E (0.75) | TP53LMNAMAPTHTR3EHTR3B | |
| SCHEMBL8565448 | 0.75 | LMNA (0.59) | TP53LMNAMAPTTHRBHTR3E | |
| SCHEMBL8569563 | 0.74 | HTR3E (0.75) | MAPTHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL22796395 | 0.74 | HTR3E (0.53) | TP53LMNAMAPTTHRBHTR3E | |
| SCHEMBL15566619 | 0.74 | GPR6 (0.69) | SMN1; SMN2USP2CASP1CASP7 | |
| SCHEMBL8567791 | 0.73 | HTR3E (0.74) | MAPTHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8571641 | 0.73 | HTR3E (0.64) | TP53LMNAHTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252195-A1 | TELOMERASE REVERSE TRANSCRIPTASE DEGRADERS AND METHODS OF USE THEREOF | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2020-12-17 | — | — | WO | disclosed |