Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | HTR3E | A5X5Y0 | 7/20 | 0.55 |
| ▸ | HTR3B | O95264 | 7/20 | 0.55 |
| ▸ | HTR3A | P46098 | 7/20 | 0.55 |
| ▸ | HTR3D | Q70Z44 | 7/20 | 0.55 |
| ▸ | HTR3C | Q8WXA8 | 7/20 | 0.55 |
| ▸ | HTR2C | P28335 | 4/20 | 0.53 |
| ▸ | HTR1A | P08908 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305565 | 0.84 | HTR1A (0.61) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8565555 | 0.80 | HTR3E (0.67) | LMNATP53MAPTTHRBHTR3E | |
| SCHEMBL22796402 | 0.76 | TP53 (0.60) | LMNATP53MAPTTHRBHTR3E | |
| SCHEMBL8569563 | 0.75 | HTR3E (0.75) | MAPTHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8569971 | 0.74 | HTR3E (0.73) | MAPTHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8565448 | 0.74 | LMNA (0.59) | LMNATP53MAPTTHRBHTR3E | |
| SCHEMBL8572446 | 0.72 | HTR3E (0.65) | LMNATP53MAPTTHRBHTR3E | |
| SCHEMBL8571231 | 0.72 | HTR3E (0.69) | LMNATP53MAPTTHRBHTR3E | |
| SCHEMBL8567791 | 0.72 | HTR3E (0.74) | MAPTHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8568649 | 0.72 | HTR3E (0.69) | MAPTHTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | disclosed |
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | disclosed |
| EP-0623620-A1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR ET COMPAGNIE (FR) | 1994-11-09 | — | — | EP | disclosed |