Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.56 |
| ▸ | HTR3B | O95264 | 4/20 | 0.56 |
| ▸ | HTR3A | P46098 | 4/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.56 |
| ▸ | HTR2C | P28335 | 4/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HTR1D | P28221 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22796402 | 0.86 | TP53 (0.60) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL15566511 | 0.76 | GPR6 (0.72) | — | |
| SCHEMBL8567807 | 0.76 | HTR2C (0.72) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL22796306 | 0.75 | HTR3E (0.57) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8567429 | 0.73 | HTR3E (0.75) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL29390362 | 0.72 | HTR3E (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL1660466 | 0.72 | HTR3E (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8569563 | 0.72 | HTR3E (0.75) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL22796308 | 0.72 | LMNA (0.57) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL31520482 | 0.71 | TSHR (0.60) | KDM4ETSHRMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252195-A1 | TELOMERASE REVERSE TRANSCRIPTASE DEGRADERS AND METHODS OF USE THEREOF | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2020-12-17 | — | — | WO | disclosed |