Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22395410 | 0.82 | P2RX7 (0.65) | P2RX7RAB9ATSHRMAPK1EPHX2 | |
| SCHEMBL2222573 | 0.81 | RAB9A (0.48) | RAB9AALDH1A1LMNASMN1; SMN2KDM4E | |
| SCHEMBL12517119 | 0.76 | P2RX7 (0.57) | P2RX7RAB9ATSHRMAPK1EPHX2 | |
| SCHEMBL3709907 | 0.75 | KMT2A (0.45) | P2RX7RAB9ATSHRMAPK1EPHX2 | |
| SCHEMBL30794592 | 0.74 | GRM5 (0.54) | P2RX7RAB9ATSHRMAPK1EPHX2 | |
| SCHEMBL2270219 | 0.74 | GRM5 (0.54) | P2RX7RAB9ATSHRMAPK1EPHX2 | |
| SCHEMBL11972371 | 0.73 | ALDH1A1 (0.61) | RAB9ATSHRMAPK1EPHX2ALDH1A1 | |
| SCHEMBL28595260 | 0.72 | P2RX7 (1.00) | P2RX7RAB9ATSHRMAPK1EPHX2 | |
| SCHEMBL2269402 | 0.72 | SMN1; SMN2 (0.50) | RAB9ATSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9914297 | 0.70 | PBK (0.55) | RAB9ATSHRMAPK1EPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011087758-A1 | ADAMANTYL AMIDE DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2011-07-21 | — | — | WO | disclosed |