Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | APLNR | P35414 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3160157 | 0.81 | APLNR (0.52) | KDM4CAPLNRALDH1A1TSHRMEN1 | |
| SCHEMBL354761 | 0.79 | APLNR (0.50) | APLNRALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL12517962 | 0.77 | KDM4C (0.51) | KDM4CAPLNRALDH1A1TSHRNPSR1 | |
| SCHEMBL320510 | 0.73 | SMN1; SMN2 (0.55) | KDM4CAPLNRALDH1A1TSHRMEN1 | |
| SCHEMBL322837 | 0.73 | GAA (0.60) | KDM4CAPLNRALDH1A1TSHRMEN1 | |
| SCHEMBL30736062 | 0.73 | KDM4C (0.60) | KDM4CAPLNRALDH1A1TSHRNPSR1 | |
| SCHEMBL14921907 | 0.72 | APLNR (0.54) | KDM4CAPLNRALDH1A1TSHRMEN1 | |
| SCHEMBL10141758 | 0.71 | APLNR (0.65) | APLNRALDH1A1TSHRNPSR1HPGD | |
| SCHEMBL29304170 | 0.71 | RAB9A (0.61) | APLNRALDH1A1TSHRNPSR1MEN1 | |
| SCHEMBL21640422 | 0.71 | APLNR (0.52) | KDM4CAPLNRALDH1A1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130059896-A1 | 5-(1H-PYRAZOL-5-YL)THIAZOLE-BASED COMPOUNDS FOR THE TREATMENT OF DISEASES AND DISORDERS OF THE EYE | LEXICON PHARMACEUTICALS, INC. | 2013-03-07 | — | — | US | disclosed |
| WO-2011091204-A1 | 5-(1H-PYRAZOL-5-YL)THIAZOLE-BASED COMPOUNDS FOR THE TREATMENT OF DISEASES AND DISORDERS OF THE EYE | LEXICON PHARMACEUTICALS, INC. (US) | 2011-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059896-A1 | 5-(1H-PYRAZOL-5-YL)THIAZOLE-BASED COMPOUNDS FOR THE TREATMENT OF DISEASES AND DISORDERS OF THE EYE | LIMK2, LIMK1, EYA2 | KDM4C 4334/4885APLNR 3882/4885ABCB1 4221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.