Sugi Predict

Sugi Predict / Compounds / SCHEMBL322837

SCHEMBL322837

SCHEMBL322837

COc1ccc(CNc2nccs2)c(OC)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 2/20 0.60
▸ APLNR P35414 1/20 0.55
▸ ALOX12 P18054 1/20 0.52
▸ ALDH1A1 P00352 4/20 0.51
▸ KDM4E B2RXH2 1/20 0.51
▸ HPGD P15428 1/20 0.51
▸ L3MBTL1 Q9Y468 1/20 0.51
▸ CYP1A2 P05177 10/20 0.50
▸ CYP3A4 P08684 10/20 0.50
▸ CYP2D6 P10635 10/20 0.50
▸ CYP2C19 P33261 9/20 0.50
▸ TSHR P16473 7/20 0.50
▸ CLK4 Q9HAZ1 7/20 0.50
▸ USP2 O75604 5/20 0.50
▸ LMNA P02545 5/20 0.50
▸ MEN1 O00255 1/20 0.50
▸ KMT2A Q03164 1/20 0.50
▸ ERBB2 P04626 1/20 0.49
▸ PRKACA P17612 1/20 0.49
▸ RPS6KB1 P23443 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15031594 0.86 GAA (0.53) GAAALOX12ALDH1A1KDM4EHPGD
SCHEMBL10185731 0.86 GAA (0.60) GAAALDH1A1KDM4EHPGDL3MBTL1
SCHEMBL14790530 0.83 GAA (0.59) GAAALOX12ALDH1A1KDM4EHPGD
SCHEMBL319266 0.79 APLNR (0.63) APLNRALDH1A1KDM4EL3MBTL1CYP1A2
SCHEMBL15011086 0.79 SMN1; SMN2 (0.66) GAAALDH1A1KDM4EHPGDL3MBTL1
SCHEMBL319454 0.78 APLNR (0.55) GAAAPLNRALDH1A1HPGDCYP1A2
SCHEMBL29736330 0.78 APLNR (0.55) GAAAPLNRALDH1A1HPGDCYP1A2
SCHEMBL320510 0.78 SMN1; SMN2 (0.55) GAAAPLNRALDH1A1HPGDCYP1A2
SCHEMBL712133 0.78 ALOX12 (0.63) GAAALOX12ALDH1A1LMNAMEN1
SCHEMBL16108929 0.77 APLNR (0.54) GAAAPLNRALDH1A1HPGDCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 182 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3983414-B1 HYDROXYPYRROLIDINE-SUBSTITUTED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS MERCK SHARP & DOHME LLC (US) 2026-04-01 — — EP disclosed
US-12427159-B2 Hydroxypyrrolidine-substituted arylsulfonamide compounds with selective activity in voltage-gated sodium channels MERCK SHARP & DOHME LLC (US) 2025-09-30 — — US disclosed
US-20240239766-A1 3-AMINO PIPERIDYL SODIUM CHANNEL INHIBITORS GENENTECH, INC. (US) 2024-07-18 — — US disclosed
US-11993595-B2 Compounds MISSION THERAPEUTICS LIMITED (GB) 2024-05-28 — — US disclosed
EP-3541373-B1 DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS MERCK SHARP & DOHME LLC (US) 2023-11-01 — — EP disclosed
EP-3541373-B1 DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS MERCK SHARP & DOHME LLC (US) 2023-11-01 — — EP disclosed
EP-3389654-B1 DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS MERCK SHARP & DOHME LLC (US) 2023-08-16 — — EP disclosed
EP-3389654-B1 DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS MERCK SHARP & DOHME LLC (US) 2023-08-16 — — EP disclosed
CN-111592534-B New compounds 特殊治疗有限公司 2023-06-30 — — CN disclosed
WO-2023028056-A1 3-AMINO PIPERIDYL SODIUM CHANNEL INHIBITORS GENENTECH, INC. (US) 2023-03-02 — — WO disclosed
EP-1995241-B1 Inhibitors of ion channels ICAGEN INC (US) 2010-03-17 — — EP disclosed
US-20090143358-A1 INHIBITORS OF ION CHANNELS ICAGEN, INC. (US) 2009-06-04 — — US disclosed
US-20090143358-A1 INHIBITORS OF ION CHANNELS ICAGEN, INC. (US) 2009-06-04 — — US disclosed
US-20090143358-A1 INHIBITORS OF ION CHANNELS ICAGEN, INC. (US) 2009-06-04 — — US disclosed
US-20090023740-A1 SODIUM CHANNEL INHIBITORS ICAGEN (US) 2009-01-22 — — US disclosed
WO-2009012242-A2 SODIUM CHANNEL INHIBITORS ICAGEN, INC. (US) 2009-01-22 — — WO disclosed
EP-1995241-A1 Inhibitors of ion channels ICAgen, Incorporated (US) 2008-11-26 — — EP disclosed
EP-1995241-A1 Inhibitors of ion channels ICAgen, Incorporated (US) 2008-11-26 — — EP disclosed
WO-2008118758-A1 INHIBITORS OF ION CHANNELS ICAGEN, INC. (GB) 2008-10-02 — — WO disclosed
WO-2008118758-A1 INHIBITORS OF ION CHANNELS ICAGEN, INC. (GB) 2008-10-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240239766-A1 3-AMINO PIPERIDYL SODIUM CHANNEL INHIBITORS CACNA1E, TRPV1, SCN3A GAA 4690/4885APLNR 189/4885ALOX12 2950/4885
US-20090023740-A1 SODIUM CHANNEL INHIBITORS TRPV1, SCN1A, SCN2A GAA 3730/4885APLNR 1302/4885ALOX12 1666/4885
US-11993595-B2 Compounds UCHL1, UCHL3, UCHL5 GAA 455/4885APLNR 3756/4885ALOX12 4054/4885
US-12427159-B2 Hydroxypyrrolidine-substituted arylsulfonamide compounds with selective activity in voltage-gated sodium channels TRPV1, SCN1A, SCN7A GAA 3905/4885APLNR 874/4885ALOX12 4226/4885
US-20090143358-A1 INHIBITORS OF ION CHANNELS TRPV1, TRPV5, TRPA1 GAA 3679/4885APLNR 1334/4885ALOX12 1302/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.