Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.59 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30698721 | 0.89 | APLNR (0.59) | APLNRALDH1A1TAS1R3TAS1R1TSHR | |
| SCHEMBL18415441 | 0.89 | TAS1R3 (0.67) | APLNRALDH1A1TAS1R3TAS1R1TSHR | |
| SCHEMBL18971053 | 0.88 | TAS1R3 (0.57) | APLNRALDH1A1TAS1R3TAS1R1TSHR | |
| SCHEMBL30849698 | 0.87 | MTNR1A (0.69) | ALDH1A1GAAPKMHPGDHTT | |
| SCHEMBL2261220 | 0.87 | APLNR (0.65) | APLNRALDH1A1TAS1R3TAS1R1TSHR | |
| SCHEMBL5570100 | 0.87 | APLNR (0.65) | APLNRMTNR1AMTNR1B | |
| SCHEMBL29209631 | 0.86 | APLNR (0.59) | APLNRALDH1A1TAS1R3TAS1R1TSHR | |
| SCHEMBL3361891 | 0.86 | APLNR (0.63) | APLNRALDH1A1TAS1R3TAS1R1TSHR | |
| SCHEMBL14521439 | 0.84 | APLNR (0.61) | APLNRALDH1A1TAS1R3TAS1R1TSHR | |
| SCHEMBL4259873 | 0.84 | APLNR (0.61) | APLNRALDH1A1TAS1R3TAS1R1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025906-A1 | KINASE MODULATORS AND METHODS OF USE THEREOF | SUNDANCE BIOSCIENCES, INC. | 2024-01-25 | — | — | US | disclosed |
| US-9181265-B2 | Substituted 2,3-dihydro-1H-benzo[a]pyrano[2,3-c]phenazines as anti-angiogenic and anti-cancer agents | UNIVERSITE CATHOLIQUE DE LOUVAIN (BE) | 2015-11-10 | — | — | US | disclosed |
| US-9181265-B2 | Substituted 2,3-dihydro-1H-benzo[a]pyrano[2,3-c]phenazines as anti-angiogenic and anti-cancer agents | UNIVERSITE CATHOLIQUE DE LOUVAIN (BE) | 2015-11-10 | — | — | US | disclosed |
| CN-104781256-A | 3,4-disubstituted oxazolidinone derivatives and their use as inhibitors of the calcium activated potassium channel | HOFFMANN LA ROCHE | 2015-07-15 | — | — | CN | disclosed |
| US-20130289030-A1 | NOVEL PHENAZINE DERIVATIVES AND THEIR USES | UNIVERSITE LIBRE DE BRUXELLES (BE) | 2013-10-31 | — | — | US | disclosed |
| US-20130289030-A1 | NOVEL PHENAZINE DERIVATIVES AND THEIR USES | UNIVERSITE LIBRE DE BRUXELLES (BE) | 2013-10-31 | — | — | US | disclosed |
| US-8569267-B2 | Tetracyclic tetrahydrofuran derivatives containing cyclic amine side chain | JANSSEN PHARMACEUTICA, NV (BE) | 2013-10-29 | — | — | US | disclosed |
| US-8569267-B2 | Tetracyclic tetrahydrofuran derivatives containing cyclic amine side chain | JANSSEN PHARMACEUTICA, NV (BE) | 2013-10-29 | — | — | US | disclosed |
| WO-2012085222-A1 | NOVEL PHENAZINE DERIVATIVES AND THEIR USE | UNIVERSITE CATHOLIQUE DE LOUVAIN (BE) | 2012-06-28 | — | — | WO | disclosed |
| US-7538241-B2 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-05-26 | — | — | US | disclosed |
| US-20080262076-A1 | Novel Tetracyclic Tetrahydrofuran Derivatives Containing Cyclic Amine Side Chain | JANSSEN PHARMACEUTICA, NV (BE) | 2008-10-23 | — | — | US | disclosed |
| US-20080262076-A1 | Novel Tetracyclic Tetrahydrofuran Derivatives Containing Cyclic Amine Side Chain | JANSSEN PHARMACEUTICA, NV (BE) | 2008-10-23 | — | — | US | disclosed |
| US-20070155813-A1 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-07-05 | — | — | US | disclosed |
| US-20070155813-A1 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-07-05 | — | — | US | disclosed |
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | PHARMACIA CORPORATION | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262076-A1 | Novel Tetracyclic Tetrahydrofuran Derivatives Containing Cyclic Amine Side Chain | HTR2C, HTR2A, HTR5A | APLNR 298/4885ALDH1A1 848/4885TAS1R3 271/4885 |
| US-20070155813-A1 | Hsp90 family protein inhibitors | HSP90AB1, HEATR1, HSP90AB2P | APLNR 4148/4885ALDH1A1 3520/4885TAS1R3 1883/4885 |
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | MAPK1, MAPK3, MAPK4 | APLNR 4127/4885ALDH1A1 1079/4885TAS1R3 3547/4885 |
| US-20130289030-A1 | NOVEL PHENAZINE DERIVATIVES AND THEIR USES | VEGFA, KDR, FLT4 | APLNR 362/4885ALDH1A1 671/4885TAS1R3 4234/4885 |
| US-20240025906-A1 | KINASE MODULATORS AND METHODS OF USE THEREOF | TYK2, JAK1, JAK3 | APLNR 2167/4885ALDH1A1 4807/4885TAS1R3 1913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.