Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 13/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.69 |
| ▸ | PGR | P06401 | 4/20 | 0.69 |
| ▸ | USP2 | O75604 | 3/20 | 0.69 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | MLNR | O43193 | 1/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.69 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.69 |
| ▸ | PPARG | P37231 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.68 |
| ▸ | DRD2 | P14416 | 1/20 | 0.68 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11236331 | 0.89 | NR3C1 (0.75) | NR3C1CYP3A4PGRUSP2NR1I2 | |
| SCHEMBL11223602 | 0.88 | NR3C1 (0.78) | NR3C1CYP3A4PGRUSP2NR1I2 | |
| SCHEMBL11232753 | 0.88 | NR3C1 (0.78) | NR3C1CYP3A4PGRUSP2NR1I2 | |
| SCHEMBL19201589 | 0.88 | NR3C1 (1.00) | NR3C1CYP3A4PGRNR1I2SMN1; SMN2 | |
| SCHEMBL11230313 | 0.87 | NR3C1 (0.81) | NR3C1CYP3A4PGRUSP2NR1I2 | |
| SCHEMBL11223884 | 0.87 | NR3C1 (0.81) | NR3C1CYP3A4PGRUSP2NR1I2 | |
| SCHEMBL19201306 | 0.87 | NR3C1 (1.00) | NR3C1CYP3A4PGRNR1I2SMN1; SMN2 | |
| SCHEMBL19201588 | 0.87 | NR3C1 (1.00) | NR3C1CYP3A4PGRNR1I2SMN1; SMN2 | |
| SCHEMBL26964859 | 0.87 | NR3C1 (1.00) | NR3C1CYP3A4PGRNR1I2SMN1; SMN2 | |
| SCHEMBL19201610 | 0.85 | NR3C1 (1.00) | NR3C1CYP3A4PGRNR1I2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230147502-A1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILIATE CELLULAR RETENTION OF COMPOUNDS | MERCK SHARP & DOHME LLC (US) | 2023-05-11 | — | — | US | disclosed |
| US-20210015930-A1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2021-01-21 | — | — | US | disclosed |
| US-10869929-B2 | Phosphonate linkers and their use to facilitate cellular retention of compounds | MERCK SHARP & DOHME CORP. (US) | 2020-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230147502-A1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILIATE CELLULAR RETENTION OF COMPOUNDS | PHOSPHO1, SLC46A1, SLC19A1 | NR3C1 4524/4885CYP3A4 4196/4885PGR 2847/4885 |
| US-20210015930-A1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS | PHOSPHO1, TK1, MSN | NR3C1 4614/4885CYP3A4 4441/4885PGR 2980/4885 |
| US-10869929-B2 | Phosphonate linkers and their use to facilitate cellular retention of compounds | PHOSPHO1, TK1, MSN | NR3C1 4614/4885CYP3A4 4441/4885PGR 2980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.