Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PON1 | P27169 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | CLK3 | P49761 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.33 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
| ▸ | HIPK3 | Q9H422 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23478525 | 0.85 | PON1 (0.36) | PON1KIF11ALDH1A1HPGDALOX15 | |
| SCHEMBL20274083 | 0.81 | EPHX2 (0.41) | KIF11ALDH1A1HSD17B10MAPTTSHR | |
| SCHEMBL2707035 | 0.79 | PON1 (0.41) | PON1KIF11ALDH1A1HPGDALOX15 | |
| SCHEMBL13561307 | 0.79 | PON1 (0.41) | PON1KIF11ALDH1A1HPGDALOX15 | |
| SCHEMBL23405763 | 0.78 | PON1 (0.40) | PON1KIF11ALDH1A1HPGDALOX15 | |
| SCHEMBL25396964 | 0.78 | PON1 (0.40) | PON1KIF11ALDH1A1HPGDALOX15 | |
| SCHEMBL23405765 | 0.78 | PON1 (0.40) | PON1KIF11ALDH1A1HPGDALOX15 | |
| SCHEMBL24779278 | 0.78 | ALDH1A1 (0.44) | PON1KIF11ALDH1A1HPGDALOX15 | |
| SCHEMBL25037452 | 0.75 | PON1 (0.51) | PON1MAPTHTR1D | |
| SCHEMBL13824710 | 0.75 | ALDH1A1 (0.45) | ALDH1A1TDP1CYP2C19MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230047816-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO PTE. LTD. (SG) | 2023-02-16 | — | — | US | disclosed |
| US-20220119385-A1 | BICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2022-04-21 | — | — | US | disclosed |
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2022-01-06 | — | — | US | disclosed |
| US-11136321-B2 | Tricyclic compounds | ALIGOS THERAPEUTICS, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2020-12-31 | — | — | US | disclosed |
| US-20200397797-A1 | HETEROCYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2020-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230047816-A1 | PFKFB3 INHIBITORS AND THEIR USES | PFKFB3, PFKFB4, PFKFB1 | PON1 3785/4885KIF11 2014/4885ALDH1A1 1943/4885 |
| US-20220119385-A1 | BICYCLIC COMPOUNDS | SLC10A1, PKD1, CYP11B2 | PON1 2581/4885KIF11 1361/4885ALDH1A1 543/4885 |
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | PON1 1719/4885KIF11 1584/4885ALDH1A1 648/4885 |
| US-11136321-B2 | Tricyclic compounds | SLC10A1, PKD1, CEL | PON1 1719/4885KIF11 1584/4885ALDH1A1 648/4885 |
| US-20200397797-A1 | HETEROCYCLIC COMPOUNDS | SLC10A1, CFTR, PKD1 | PON1 2351/4885KIF11 2118/4885ALDH1A1 296/4885 |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | PON1 1719/4885KIF11 1584/4885ALDH1A1 648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.