Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27118659 | 0.89 | NAMPT (0.42) | NAMPTGSK3BDYRK1ALMNATDP1 | |
| SCHEMBL21316476 | 0.88 | NAMPT (0.46) | NAMPTGSK3BDYRK1AMEN1POLB | |
| SCHEMBL29790453 | 0.87 | NAMPT (0.46) | NAMPTGSK3BDYRK1AMEN1KMT2A | |
| SCHEMBL18574433 | 0.86 | NAMPT (0.45) | NAMPTMEN1LMNAPOLBPKM | |
| SCHEMBL19739249 | 0.84 | SCN3A (0.41) | NAMPTGSK3BDYRK1AMAP4K4SCN3A | |
| SCHEMBL19739081 | 0.83 | SMN1; SMN2 (0.43) | MAP4K4LMNAPOLBKMT2ASCN3A | |
| SCHEMBL2390936 | 0.82 | GSK3B (0.40) | NAMPTGSK3BDYRK1AMEN1KMT2A | |
| SCHEMBL2389887 | 0.82 | GSK3B (0.40) | NAMPTGSK3BDYRK1AMEN1KMT2A | |
| SCHEMBL6428501 | 0.81 | GSK3B (0.41) | NAMPTGSK3BDYRK1AMEN1KMT2A | |
| SCHEMBL26073602 | 0.81 | CYP17A1 (0.43) | NAMPTGSK3BDYRK1AMAP4K4SCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11793885-B2 | Substituted benzo[5,6][1,4]diazepino[1,2-a]indoles for the treatment of proliferative disorders | IMMUNOGEN, INC. (US) | 2023-10-24 | — | — | US | disclosed |
| US-20200397914-A1 | BENZODIAZEPINE DERIVATIVES | IMMUNOGEN, INC. | 2020-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200397914-A1 | BENZODIAZEPINE DERIVATIVES | GABRA5, GABRA3, GABRA1 | NAMPT 4296/4885MAPKAPK2 3317/4885GSK3B 125/4885 |
| US-11793885-B2 | Substituted benzo[5,6][1,4]diazepino[1,2-a]indoles for the treatment of proliferative disorders | MKI67, GABBR1, GABBR2 | NAMPT 4244/4885MAPKAPK2 4003/4885GSK3B 158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.