Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10993388 | 0.87 | ALDH1A1 (0.55) | ALDH1A1HPGDL3MBTL1GLATDP1 | |
| SCHEMBL28544550 | 0.84 | ALDH1A1 (0.64) | ALDH1A1HPGDL3MBTL1GLATDP1 | |
| SCHEMBL10746787 | 0.78 | HPGD (0.64) | ALDH1A1HPGDL3MBTL1GLATDP1 | |
| SCHEMBL10986557 | 0.75 | KDM4E (0.54) | ALDH1A1HPGDL3MBTL1MAPTKMT2A | |
| SCHEMBL7812395 | 0.73 | CYP11B2 (0.58) | ALDH1A1HPGDL3MBTL1GLATDP1 | |
| SCHEMBL22004148 | 0.73 | KMT2A (0.54) | ALDH1A1HPGDL3MBTL1GLATDP1 | |
| SCHEMBL28369714 | 0.73 | GABRA1 (0.50) | ALDH1A1HPGDL3MBTL1GLATDP1 | |
| SCHEMBL22022202 | 0.73 | PLA2G2A (0.52) | ALDH1A1HPGDL3MBTL1GLATDP1 | |
| SCHEMBL13006958 | 0.72 | SCN9A (0.53) | ALDH1A1HPGDL3MBTL1GLATDP1 | |
| SCHEMBL15687530 | 0.72 | ALDH1A1 (0.50) | ALDH1A1HPGDL3MBTL1GLATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110207732-A1 | AZAINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-08-25 | — | — | US | claimed |
| US-20110207732-A1 | AZAINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-08-25 | — | — | US | disclosed |
| WO-2010046013-A1 | AZAINDOLE DERIVATIVE | MERCK PATENT GMBH (DE) | 2010-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207732-A1 | AZAINDOLE DERIVATIVES | AZI2, ABL1, RET | ALDH1A1 2134/4885HPGD 4063/4885L3MBTL1 1289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.