Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12578946 | 0.79 | ATR (0.47) | ATRPOLBNAMPTSCN10AMAPK1 | |
| SCHEMBL2285550 | 0.78 | CYP3A4 (0.50) | SYKALDH1A1POLBNAMPTMAPK1 | |
| SCHEMBL1185840 | 0.77 | SYK (0.57) | SYKEPHX2PPARGATM | |
| SCHEMBL29142186 | 0.74 | CASP3 (0.43) | EPHX2ALDH1A1MAPTPOLBPPARG | |
| SCHEMBL17592938 | 0.74 | CTSS (0.49) | SYKEPHX2PPARG | |
| Trifluoroacetic Acid SCHEMBL7348672 | 0.73 | SYK (0.53) | SYKEPHX2PPARGATM | |
| SCHEMBL31098519 | 0.73 | BRD4 (0.50) | MAPTNAMPTL3MBTL1KCNA5 | |
| SCHEMBL2261228 | 0.72 | EPHX2 (0.41) | SYKEPHX2ALDH1A1MAPTPPARG | |
| SCHEMBL14631440 | 0.72 | MEN1 (0.45) | SYKALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2799915 | 0.71 | EPHX2 (0.59) | SYKEPHX2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110207783-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2011-08-25 | — | — | US | disclosed |
| EP-2188256-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009018662-A9 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2010-04-08 | — | — | WO | disclosed |
| WO-2009018662-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207783-A1 | RENIN INHIBITORS | REN, ACE, AGT | SYK 4174/4885EPHX2 700/4885ATR 1693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.