Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12848670 | 0.85 | TSHR (0.43) | TSHRATMCYP3A4ZDHHC20ALDH1A1 | |
| SCHEMBL22856582 | 0.84 | TSHR (0.42) | TSHRATMCYP3A4ZDHHC20ALDH1A1 | |
| SCHEMBL12452054 | 0.84 | TSHR (0.42) | TSHRATMCYP3A4ZDHHC20ALDH1A1 | |
| SCHEMBL6859349 | 0.81 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2AEPHX2 | |
| SCHEMBL22793905 | 0.79 | TSHR (0.45) | TSHRATMCYP3A4ZDHHC20ALDH1A1 | |
| SCHEMBL16355252 | 0.79 | THRA (0.38) | TSHRCYP3A4ZDHHC20ALDH1A1CES2 | |
| SCHEMBL10341550 | 0.79 | CES2 (0.47) | ZDHHC20CES2DNM1MEN1KMT2A | |
| SCHEMBL24572499 | 0.78 | TSHR (0.43) | TSHRATMCYP3A4ZDHHC20ALDH1A1 | |
| SCHEMBL24572131 | 0.78 | TSHR (0.43) | TSHRATMCYP3A4ZDHHC20ALDH1A1 | |
| SCHEMBL1377069 | 0.76 | TSHR (0.42) | TSHRATMCYP3A4ALDH1A1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020264490-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | disclosed |