Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11250568 | 0.84 | DPP4 (0.44) | MEN1KMT2AGRIN2BALDH1A1CYP2A13 | |
| SCHEMBL14840330 | 0.81 | TSHR (0.43) | MEN1KMT2AGRIN2BALDH1A1CYP2A13 | |
| SCHEMBL22857083 | 0.81 | GRIN2B (0.41) | MEN1KMT2AGRIN2BALDH1A1CYP2A13 | |
| SCHEMBL17848532 | 0.80 | RIPK1 (0.46) | MEN1KMT2AGRIN2BALDH1A1METAP2 | |
| SCHEMBL20147361 | 0.80 | OPRM1 (0.44) | MEN1KMT2AGRIN2BALDH1A1OPRM1 | |
| SCHEMBL10192225 | 0.80 | ALDH1A1 (0.44) | MEN1KMT2AGRIN2BALDH1A1TAAR1 | |
| SCHEMBL10191864 | 0.80 | ALDH1A1 (0.44) | MEN1KMT2AGRIN2BALDH1A1TAAR1 | |
| SCHEMBL376474 | 0.79 | OPRL1 (0.54) | MEN1KMT2AALDH1A1OPRL1GAA | |
| Hydrochloric Acid SCHEMBL10502200 | 0.78 | POLB (0.55) | MEN1KMT2AALDH1A1OPRL1GAA | |
| SCHEMBL11542738 | 0.77 | SIGMAR1 (0.49) | OPRM1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10881652-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2021-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10881652-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, BRAF, RAF1 | MEN1 653/4885KMT2A 1112/4885GRIN2B 1206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.