Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20069595 | 0.85 | UTS2R (0.45) | GRIN2BUTS2RKMT2AALDH1A1KDM4E | |
| SCHEMBL20147382 | 0.81 | OPRM1 (0.46) | GRIN2BUTS2RALDH1A1KDM4EOPRM1 | |
| SCHEMBL22857082 | 0.81 | MEN1 (0.41) | GRIN2BKMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL5348277 | 0.80 | GRIN2B (0.41) | GRIN2BKMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL7290612 | 0.77 | LMNA (0.46) | GRIN2BKMT2AOPRM1MEN1LMNA | |
| SCHEMBL20205978 | 0.76 | OPRL1 (0.61) | GRIN2BOPRM1OPRD1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL20137513 | 0.75 | LMNA (0.49) | GRIN2BKMT2AOPRM1OPRL1MEN1 | |
| SCHEMBL377048 | 0.74 | CHRNA10 (0.42) | KDM4EPOLBOPRM1OPRD1OPRK1 | |
| SCHEMBL376479 | 0.73 | MAPK1 (0.41) | GRIN2BUTS2RKMT2AALDH1A1KDM4E | |
| SCHEMBL20206044 | 0.71 | PKLR (0.44) | KMT2AOPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10881652-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2021-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10881652-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, BRAF, RAF1 | GRIN2B 1206/4885UTS2R 384/4885KMT2A 1112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.