Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PARG | Q86W56 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22862994 | 0.92 | KDM4E (0.37) | KDM4ESMN1; SMN2MAPK14TSHRL3MBTL1 | |
| SCHEMBL22862944 | 0.85 | MAPK14 (0.38) | KDM4ESMN1; SMN2MAPK14TSHRL3MBTL1 | |
| SCHEMBL22862773 | 0.85 | CYP11B2 (0.38) | KDM4ESMN1; SMN2MAPK14TSHRL3MBTL1 | |
| SCHEMBL29490282 | 0.84 | THRB (0.40) | KDM4ESMN1; SMN2TSHRL3MBTL1TP53 | |
| SCHEMBL22862559 | 0.84 | THRB (0.40) | KDM4ESMN1; SMN2TSHRL3MBTL1TP53 | |
| SCHEMBL22862877 | 0.83 | SIGMAR1 (0.39) | — | |
| SCHEMBL22862770 | 0.83 | KDM4E (0.33) | KDM4EMAPK14PDE1CALDH1A1CYP11B2 | |
| SCHEMBL22862640 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2TSHRL3MBTL1TP53LMNA | |
| SCHEMBL29490281 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2TSHRL3MBTL1TP53LMNA | |
| SCHEMBL22862548 | 0.82 | POLB (0.45) | SMN1; SMN2MAPK14TSHRL3MBTL1PDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220389028-A1 | BAX INHIBITORS AND USES THEREOF | CASE WESTERN RESERVE UNIVERSITY | 2022-12-08 | — | — | US | disclosed |
| WO-2021002986-A2 | BAX INHIBITORS AND USES THEREOF | CASE WESTERN RESERVE UNIVERSITY (US) | 2021-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220389028-A1 | BAX INHIBITORS AND USES THEREOF | BAX, TMBIM6, BCL2 | KDM4E 4111/4885SMN1; SMN2 2633/4885MAPK14 765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.