SCHEMBL2286343

SCHEMBL2286343

COc1c[c]cc(F)c1Cl

nearest known ligand 0.32

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.32
HTR2A P28223 3/20 0.32
SLC6A4 P31645 1/20 0.32
KCNH2 Q12809 1/20 0.32
HTR2C P28335 2/20 0.32
HTR2B P41595 2/20 0.32
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL499678 0.84 CA12 (0.35) HTR2AHTR2CHTR2B
SCHEMBL2288733 0.77 TUBB1 (0.33) LMNA
SCHEMBL2282004 0.77 GAA (0.35) TAAR1
SCHEMBL2285774 0.76 TUBB1 (0.34)
SCHEMBL944353 0.76 ACHE (0.34) HTR2AHTR2CHTR2B
SCHEMBL2284733 0.76 PDE3B (0.32)
SCHEMBL2288168 0.74 GAA (0.33) HTR2AHTR2CHTR2BLMNA
SCHEMBL2286239 0.74 POLB (0.34)
SCHEMBL4049001 0.74 ALOX5 (0.39) LMNA
SCHEMBL2285493 0.74 MAPT (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101115723-B Pyrazole carboxylic acid anilides, method for the production thereof and agents containing them for controlling pathogenic fungi BASF AG (DE) 2012-02-22 CN disclosed
US-8008232-B2 Such as N-(3',4'-dichlorobiphenyl-2-yl)-5-chloro-1,3-dimethyl-1H-pyrazole-4-carboxamide; seeds BASF AKTIENGESELLSCHAFT (DE) 2011-08-30 US disclosed
US-7989394-B2 Substituted 1-(azolin-2-yl)-amino-2-aryl-1-hetaryl-ethane compounds BASF SE (DE) 2011-08-02 US disclosed
US-20090131256-A1 Substituted 1-(azolin-2-yl)-amino-2-aryl-1-hetaryl-ethane Compounds BASF SE (DE) 2009-05-21 US disclosed
US-20080153707-A1 Pyrazolecarboxanilides, Process for Their Preparation and Compositions Comprising Them for Controlling Harmful Fungi BASF AKITENGESELLSCHAFT (DE) 2008-06-26 US disclosed
CN-101115723-A Pyrazole carboxylic acid anilides, method for the production thereof and agents containing them for controlling pathogenic fungi BASF AG (DE) 2008-01-30 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080153707-A1 Pyrazolecarboxanilides, Process for Their Preparation and Compositions Comprising Them for Controlling Harmful Fungi CBR3, C1S, PYM1 TAAR1 2210/4885HTR2A 2772/4885SLC6A4 4393/4885
US-20090131256-A1 Substituted 1-(azolin-2-yl)-amino-2-aryl-1-hetaryl-ethane Compounds AAAS, AIPL1, ATXN2 TAAR1 252/4885HTR2A 649/4885SLC6A4 4493/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.