Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.31 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533056 | 0.85 | DBH (0.33) | ACHEPDGFRBPDGFRATUBB1 | |
| SCHEMBL76231 | 0.83 | ACHE (0.48) | ACHECYP3A4MAPTCA9HTR2A | |
| SCHEMBL27863792 | 0.82 | HTR2A (0.42) | MAPTHTR2AHTR2CHTR2BPTGS2 | |
| Fluoride SCHEMBL28104198 | 0.80 | ACHE (0.46) | ACHECYP3A4MAPTCA9HTR2A | |
| SCHEMBL2288733 | 0.79 | TUBB1 (0.33) | CA9NFE2L2TUBB1 | |
| SCHEMBL2285774 | 0.77 | TUBB1 (0.34) | ACHENFE2L2TUBB1 | |
| SCHEMBL2284682 | 0.77 | ACHE (0.30) | ACHE | |
| SCHEMBL2285493 | 0.76 | MAPT (0.32) | MAPT | |
| SCHEMBL2286343 | 0.76 | TAAR1 (0.32) | HTR2AHTR2CHTR2B | |
| SCHEMBL4049001 | 0.76 | ALOX5 (0.39) | CYP3A4MAPTCA9PTGS2NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118206551-A | Quinoline compounds, their preparation and their use as antimalarial agents | 美国卫生和人力服务部 | 2024-06-18 | — | — | CN | claimed |
| US-20210188843-A1 | QUINOLINE COMPOUNDS AND THEIR PREPARATION AND USE AS ANTIMALARIAL AGENTS | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-06-24 | — | — | US | claimed |
| CN-112334468-A | Quinoline compounds, their preparation and use as antimalarial agents | 美国卫生和人力服务部 | 2021-02-05 | — | — | CN | claimed |
| US-10106516-B2 | PDE10 inhibitors and related compositions and methods | OMEROS CORPORATION (US) | 2018-10-23 | — | — | US | claimed |
| US-20170152238-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION | 2017-06-01 | — | — | US | claimed |
| CN-118206551-A | Quinoline compounds, their preparation and their use as antimalarial agents | 美国卫生和人力服务部 | 2024-06-18 | — | — | CN | disclosed |
| CN-116547273-A | Herbicidal derivatives | 先正达农作物保护股份公司 | 2023-08-04 | — | — | CN | disclosed |
| US-20210188843-A1 | QUINOLINE COMPOUNDS AND THEIR PREPARATION AND USE AS ANTIMALARIAL AGENTS | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-06-24 | — | — | US | disclosed |
| EP-3790878-A1 | QUINOLINE COMPOUNDS AND THEIR PREPARATION AND USE AS ANTIMALARIAL AGENTS | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2021-03-17 | — | — | EP | disclosed |
| CN-112334468-A | Quinoline compounds, their preparation and use as antimalarial agents | 美国卫生和人力服务部 | 2021-02-05 | — | — | CN | disclosed |
| WO-2019217957-A1 | QUINOLINE COMPOUNDS AND THEIR PREPARATION AND USE AS ANTIMALARIAL AGENTS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-11-14 | — | — | WO | disclosed |
| US-20130310358-A1 | PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2013-11-21 | — | — | US | disclosed |
| US-20110218205-A1 | Piperazine derivatives | M'S SCIENCE CORP. | 2011-09-08 | — | — | US | disclosed |
| US-7989394-B2 | Substituted 1-(azolin-2-yl)-amino-2-aryl-1-hetaryl-ethane compounds | BASF SE (DE) | 2011-08-02 | — | — | US | disclosed |
| US-7985751-B2 | Piperazine derivatives | M'S SCIENCE CORPORATION (JP) | 2011-07-26 | — | — | US | disclosed |
| US-20110021539-A1 | Pyrazinylpyrazoles | BAYER CROPSCIENCE AG (DE) | 2011-01-27 | — | — | US | disclosed |
| US-20090143395-A1 | Piperazine Derivatives | SUN CONNIE L | 2009-06-04 | — | — | US | disclosed |
| US-20090131256-A1 | Substituted 1-(azolin-2-yl)-amino-2-aryl-1-hetaryl-ethane Compounds | BASF SE (DE) | 2009-05-21 | — | — | US | disclosed |
| EP-1931347-A2 | PIPERAZINE DERIVATIVES | M's Science Corporation (JP) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007021545-A2 | PIPERAZINE DERIVATIVES | M'S SCIENCE CORPORATION (JP) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10106516-B2 | PDE10 inhibitors and related compositions and methods | PDE10A, PDE9A, PDE7A | ACHE 30/4885CYP3A4 908/4885MAPT 229/4885 |
| US-20110021539-A1 | Pyrazinylpyrazoles | CYP4F3, CYP4B1, CYP1A2 | ACHE 52/4885CYP3A4 9/4885MAPT 2855/4885 |
| US-20130310358-A1 | PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS | OPRD1, OPRK1, OPRM1 | ACHE 707/4885CYP3A4 1552/4885MAPT 2667/4885 |
| US-20170152238-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | PDE10A, PDE9A, PDE7A | ACHE 30/4885CYP3A4 908/4885MAPT 229/4885 |
| US-20090131256-A1 | Substituted 1-(azolin-2-yl)-amino-2-aryl-1-hetaryl-ethane Compounds | AAAS, AIPL1, ATXN2 | ACHE 813/4885CYP3A4 2419/4885MAPT 4268/4885 |
| US-20090143395-A1 | Piperazine Derivatives | SIGMAR1, OPRK1, OPRL1 | ACHE 1000/4885CYP3A4 1162/4885MAPT 3236/4885 |
| US-20110218205-A1 | Piperazine derivatives | SIGMAR1, OPRK1, OPRM1 | ACHE 912/4885CYP3A4 908/4885MAPT 3011/4885 |
| US-20210188843-A1 | QUINOLINE COMPOUNDS AND THEIR PREPARATION AND USE AS ANTIMALARIAL AGENTS | GLS2, RECQL, PYGL | ACHE 332/4885CYP3A4 66/4885MAPT 3651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.