Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | CA3 | P07451 | 3/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA4 | P22748 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL501727 | 0.97 | ALOX15 (0.57) | ALOX15CA3CA14HSD17B10MAPT | |
| Bromide SCHEMBL11133148 | 0.93 | ALOX15 (0.53) | ALOX15CA3CA14HSD17B10MAPT | |
| Hydrochloric Acid SCHEMBL3142697 | 0.89 | CA12 (0.50) | ALOX15CA3CA14HSD17B10MAPT | |
| SCHEMBL158163 | 0.85 | CA12 (0.53) | ALOX15CA3CA14HSD17B10MAPT | |
| SCHEMBL502108 | 0.85 | CA12 (0.53) | ALOX15CA3CA14HSD17B10MAPT | |
| SCHEMBL12639140 | 0.83 | MAPK1 (0.50) | ALOX15CA3CA14HSD17B10MAPT | |
| SCHEMBL6117392 | 0.83 | GAA (0.45) | ALOX15CA3CA14HSD17B10MAPT | |
| Water SCHEMBL548229 | 0.83 | CA12 (0.50) | ALOX15CA3CA14HSD17B10MAPT | |
| SCHEMBL12770101 | 0.83 | ACHE (0.68) | ALOX15CA3CA14HSD17B10MAPT | |
| SCHEMBL10022934 | 0.83 | ACHE (0.68) | ALOX15CA3CA14HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4399233-A | Process for preparing low molecular weight oxygenated compounds from syngas using novel catalyst system | TEXACO INC. (US) | 1983-08-16 | — | — | US | claimed |
| US-20140342291-A1 | Novel Dual-Tone Resist Formulations And Methods | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-11-20 | — | — | US | disclosed |
| EP-2199856-B1 | Cationic radiation curable compositions | AGFA GRAPHICS NV (BE) | 2013-08-07 | — | — | EP | disclosed |
| WO-2011133680-A2 | NOVEL DUAL-TONE RESIST FORMULATIONS AND METHODS | BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-10-27 | — | — | WO | disclosed |
| US-20110262860-A1 | NOVEL DUAL-TONE RESIST FORMULATIONS AND METHODS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS | 2011-10-27 | — | — | US | disclosed |
| US-20110195194-A1 | CATIONIC RADIATION CURABLE COMPOSITIONS | AGFA GRAPHICS NV (BE) | 2011-08-11 | — | — | US | disclosed |
| WO-2010069754-A1 | CATIONIC RADIATION CURABLE COMPOSITIONS | AGFA GRAPHICS NV (BE) | 2010-06-24 | — | — | WO | disclosed |
| EP-2199856-A1 | Cationic radiation curable compositions | Agfa Graphics N.V. (BE) | 2010-06-23 | — | — | EP | disclosed |
| EP-0410263-B1 | Cationic photoinitiated polymerisation process and the preparation of relief motifs or photoimages using sulfonium salts | BASF AG (DE) | 1994-02-16 | — | — | EP | disclosed |
| US-5220037-A | Photoinitiators for cationic polymerization | BASF AKTIENGESELLSCHAFT (DE) | 1993-06-15 | — | — | US | disclosed |
| US-5159088-A | Photinitiators for cationic polymerization | BASF AKTIENGESELLSCHAFT (DE) | 1992-10-27 | — | — | US | disclosed |
| EP-0410263-A1 | Cationic photoinitiated polymerisation process and the preparation of relief motifs or photoimages using sulfonium salts | BASF Aktiengesellschaft (DE) | 1991-01-30 | — | — | EP | disclosed |
| US-4399233-A | Process for preparing low molecular weight oxygenated compounds from syngas using novel catalyst system | TEXACO INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4391992-A | N-Denitration of N,2,6-trinitroanilines with phase transfer catalysts | AMERICAN CYANAMID COMPANY (US) | 1983-07-05 | — | — | US | disclosed |
| US-4348319-A | REACTION OF HALO-AZO DYE WITH COPPER CYANIDE IN WATER IN PRESENCE OF PHASE TRANSFER AGENT | BAYER AKTIENGESELLSCHAFT (DE) | 1982-09-07 | — | — | US | disclosed |
| EP-0049384-A1 | N-denitration of N,2,6-trinitroanilines with phase transfer catalysts | AMERICAN CYANAMID COMPANY (US) | 1982-04-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195194-A1 | CATIONIC RADIATION CURABLE COMPOSITIONS | NR2E3, NR2E1, CCNE2 | ACHE 4208/4885ALOX15 1334/4885CA3 1652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.