Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22877184 | 0.91 | POLB (0.44) | ALDH1A1SMN1; SMN2L3MBTL1POLBKMT2A | |
| SCHEMBL26429710 | 0.88 | L3MBTL1 (0.38) | TSHREGFRALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL26429458 | 0.86 | ALDH1A1 (0.40) | TSHRALDH1A1SMN1; SMN2L3MBTL1POLB | |
| SCHEMBL26705254 | 0.86 | POLB (0.42) | ALDH1A1SMN1; SMN2L3MBTL1POLBKMT2A | |
| SCHEMBL22877375 | 0.79 | POLB (0.40) | EGFRALDH1A1POLBLMNAGAA | |
| SCHEMBL22877204 | 0.79 | POLB (0.40) | EGFRALDH1A1POLBLMNAGAA | |
| SCHEMBL26705039 | 0.73 | POLB (0.39) | EGFRALDH1A1POLBLMNAGAA | |
| SCHEMBL26429346 | 0.71 | CYP2D6 (0.39) | ALDH1A1CYP3A4 | |
| SCHEMBL22877140 | 0.71 | POLB (0.41) | TSHRALDH1A1L3MBTL1POLBKMT2A | |
| SCHEMBL22877195 | 0.70 | POLB (0.38) | EGFRALDH1A1SMN1; SMN2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339879-A1 | SUBSTITUTED CHROMANES, ANALOGS THEREOF, AND METHODS OF USE AND SYNTHESIS | NORTHWESTERN UNIVERSITY | 2023-10-26 | — | — | US | disclosed |
| US-11639340-B2 | Substituted chromanes, analogs thereof, and methods of use and synthesis | NORTHWESTERN UNIVERSITY (US) | 2023-05-02 | — | — | US | disclosed |
| US-20210009547-A1 | SUBSTITUTED CHROMANES, ANALOGS THEREOF, AND METHODS OF USE AND SYNTHESIS | NORTHWESTERN UNIVERSITY (US) | 2021-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210009547-A1 | SUBSTITUTED CHROMANES, ANALOGS THEREOF, AND METHODS OF USE AND SYNTHESIS | TYR, ME1, PNPO | TSHR 861/4885EGFR 1971/4885ALDH1A1 444/4885 |
| US-11639340-B2 | Substituted chromanes, analogs thereof, and methods of use and synthesis | TYR, ME1, PNPO | TSHR 861/4885EGFR 1971/4885ALDH1A1 444/4885 |
| US-20230339879-A1 | SUBSTITUTED CHROMANES, ANALOGS THEREOF, AND METHODS OF USE AND SYNTHESIS | TYR, ME1, PNPO | TSHR 861/4885EGFR 1971/4885ALDH1A1 444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.