Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | CYP1A1 | P04798 | 9/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.57 |
| ▸ | CYP1B1 | Q16678 | 9/20 | 0.57 |
| ▸ | P4HB | P07237 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | JUN | P05412 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29496403 | 1.00 | ALDH1A1 (0.62) | ALDH1A1CYP1A1CYP1A2CYP1B1P4HB | |
| SCHEMBL11222093 | 0.86 | P4HB (0.68) | ALDH1A1CYP1A2P4HBCYP3A4LMNA | |
| SCHEMBL4407110 | 0.86 | P4HB (0.68) | ALDH1A1CYP1A2P4HBCYP3A4LMNA | |
| SCHEMBL8996130 | 0.85 | ALDH1A1 (0.61) | ALDH1A1CYP1A1CYP1A2CYP1B1CYP3A4 | |
| SCHEMBL22887222 | 0.85 | P4HB (0.57) | ALDH1A1CYP1A1CYP1A2CYP1B1P4HB | |
| SCHEMBL8996089 | 0.85 | ALDH1A1 (0.61) | ALDH1A1CYP1A1CYP1A2CYP1B1CYP3A4 | |
| SCHEMBL22887220 | 0.85 | P4HB (0.57) | ALDH1A1CYP1A1CYP1A2CYP1B1P4HB | |
| SCHEMBL8996085 | 0.85 | ALDH1A1 (0.61) | ALDH1A1CYP1A1CYP1A2CYP1B1CYP3A4 | |
| SCHEMBL5922410 | 0.84 | CHEK1 (0.49) | ALDH1A1CYP1A1CYP1A2CYP1B1P4HB | |
| SCHEMBL5922414 | 0.84 | CHEK1 (0.49) | ALDH1A1CYP1A1CYP1A2CYP1B1P4HB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858889-B2 | Compound for modulating DDAH and ADMA levels, as well as methods of using thereof to treat disease | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2024-01-02 | — | — | US | disclosed |
| US-20210009498-A1 | COMPOUND FOR MODULATING DDAH AND ADMA LEVELS, AS WELL AS METHODS OF USING THEREOF TO TREAT DISEASE | THE TRUSTEES OF INDIANA UNIVERSITY | 2021-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11858889-B2 | Compound for modulating DDAH and ADMA levels, as well as methods of using thereof to treat disease | ADM2, DDAH1, BHMT | ALDH1A1 336/4885CYP1A1 1071/4885CYP1A2 1125/4885 |
| US-20210009498-A1 | COMPOUND FOR MODULATING DDAH AND ADMA LEVELS, AS WELL AS METHODS OF USING THEREOF TO TREAT DISEASE | ADM2, DDAH1, BHMT | ALDH1A1 336/4885CYP1A1 1071/4885CYP1A2 1125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.