Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | DBH | P09172 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22889639 | 0.90 | GAA (0.53) | GAAKDM4EDBHRECQLFFAR1 | |
| SCHEMBL10744489 | 0.87 | RECQL (0.42) | GAAKDM4EDBHRECQLFFAR1 | |
| SCHEMBL22889592 | 0.78 | KDM4E (0.59) | GAAKDM4EDBHRECQLFFAR1 | |
| SCHEMBL9962964 | 0.78 | GAA (0.56) | GAAKDM4EDBHRECQLFFAR1 | |
| SCHEMBL27599090 | 0.78 | GAA (0.69) | GAAKDM4EDBHRECQLFFAR1 | |
| SCHEMBL6357899 | 0.77 | KDM4E (0.63) | GAAKDM4EDBHRECQLFFAR1 | |
| SCHEMBL10819621 | 0.77 | KDM4E (0.47) | GAAKDM4EDBHRECQLFFAR1 | |
| SCHEMBL13410609 | 0.77 | GAA (0.57) | GAAKDM4EDBHRECQLFFAR1 | |
| SCHEMBL16256439 | 0.75 | KDM4E (0.54) | GAAKDM4EDBHRECQLFFAR1 | |
| SCHEMBL10146785 | 0.74 | KDM4E (0.44) | GAAKDM4EDBHRECQLFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210009551-A1 | COMPOUNDS AND METHODS FOR TREATING FIBROSIS OR CANCER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2021-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210009551-A1 | COMPOUNDS AND METHODS FOR TREATING FIBROSIS OR CANCER | MMP1, MMP8, SERPINB1 | GAA 1080/4885KDM4E 2804/4885DBH 1159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.