SCHEMBL2289115

SCHEMBL2289115

Fc1ccc(-c2nnc(-c3ccc(F)cc3)o2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 7/20 1.00
RAB9A P51151 6/20 1.00
SMN1; SMN2 Q16637 3/20 0.79
TP53 P04637 3/20 0.79
TSHR P16473 2/20 0.79
HSD17B10 Q99714 1/20 0.79
USP2 O75604 1/20 0.69
POLB P06746 1/20 0.69
MAOA P21397 2/20 0.66
MAOB P27338 2/20 0.66
KDM4E B2RXH2 1/20 0.59
NOTUM Q6P988 2/20 0.56
ACHE P22303 1/20 0.55
PKM P14618 1/20 0.54
ADCY1 Q08828 1/20 0.53
GUSB P08236 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29210254 0.91 NPC1 (0.83) NPC1RAB9ASMN1; SMN2TP53TSHR
SCHEMBL19010395 0.89 NPC1 (0.79) NPC1RAB9ASMN1; SMN2TP53TSHR
SCHEMBL28671885 0.89 NPC1 (0.79) NPC1RAB9ASMN1; SMN2TP53TSHR
SCHEMBL15088407 0.86 NPC1 (0.75) NPC1RAB9ASMN1; SMN2TP53TSHR
SCHEMBL2159951 0.86 NPC1 (0.74) NPC1RAB9ASMN1; SMN2TP53TSHR
SCHEMBL23451582 0.84 NPC1 (0.72) NPC1RAB9ASMN1; SMN2TP53TSHR
SCHEMBL2360471 0.84 NPC1 (0.72) NPC1RAB9ASMN1; SMN2TP53TSHR
SCHEMBL9848053 0.84 NPC1 (0.72) NPC1RAB9ASMN1; SMN2TP53TSHR
SCHEMBL20767009 0.84 NPC1 (0.72) NPC1RAB9ASMN1; SMN2TP53TSHR
SCHEMBL19558149 0.84 NPC1 (0.72) NPC1RAB9ASMN1; SMN2TP53TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250101295-A1 THERMALLY ACTIVATED DELAYED FLUORESCENCE CHROMOPHORES AND ORGANIC LAYERS INCLUDING THE SAME WRIGHT STATE UNIVERSITY (US) 2025-03-27 US claimed
US-20200131436-A1 THERMALLY ACTIVATED DELAYED FLUORESCENCE CHROMOPHORES AND ORGANIC LAYERS INCLUDING THE SAME WRIGHT STATE UNIVERSITY (US) 2020-04-30 US claimed
US-20140308600-A1 Novel Polymer Networks Based on the Benzimidazole Moiety for High Performance Polymer Electrolyte Membrane Fuel Cells Advent Technologies Inc. (US) 2014-10-16 US claimed
US-8247521-B2 Acid-doped polyelectrolyte modified carbon nanotubes and their use in high temperature PEM fuel cell electrodes ADVENT TECHNOLOGIES (GR) 2012-08-21 US claimed
WO-2009087484-A2 ACID-DOPED POLYELECTROLYTE MODIFIED CARBON NANOTUBES AND THEIR USE IN HIGH TEMPERATURE PEM FUEL CELL ELECTRODES ADVENT TECHNOLOGIES (US) 2009-07-16 WO claimed
US-20090081487-A1 Acid-Doped Polyelectrolyte Modified Carbon Nanotubes and their Use in High Temperature PEM Fuel Cell Electrodes ADVENT TECHNOLOGIES (GR) 2009-03-26 US claimed
US-7318964-B2 Fluorene compounds containing various functional groups, polymers thereof and EL element using the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2008-01-15 US claimed
US-20020193522-A1 Synthesis and luminescent characteristics of novel phosphorus containing light-emitting polymers SUN YIH-MIN (TW) 2002-12-19 US claimed
US-20250101295-A1 THERMALLY ACTIVATED DELAYED FLUORESCENCE CHROMOPHORES AND ORGANIC LAYERS INCLUDING THE SAME WRIGHT STATE UNIVERSITY (US) 2025-03-27 US disclosed
US-12187934-B2 Thermally activated delayed fluorescence chromophores and organic layers including the same WRIGHT STATE UNIVERSITY (US) 2025-01-07 US disclosed
US-20240141134-A1 COMPOSITIONS, ARTICLES, AND METHODS RELATED TO HYDROGEN GAS SENSORS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2024-05-02 US disclosed
EP-3789451-A1 POROUS CYCLODEXTRIN POLYMERIC MATERIALS Cornell University (US) 2021-03-10 EP disclosed
US-20210053025-A1 POROUS CYCLODEXTRIN POLYMERIC MATERIALS AND METHODS OF MAKING AND USING SAME CORNELL UNIVERSITY 2021-02-25 US disclosed
EP-3286261-B1 POROUS CYCLODEXTRIN POLYMERIC MATERIALS AND METHODS OF MAKING SAME UNIV CORNELL (US) 2020-10-21 EP disclosed
US-7318964-B2 Fluorene compounds containing various functional groups, polymers thereof and EL element using the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2008-01-15 US disclosed
US-7318964-B2 Fluorene compounds containing various functional groups, polymers thereof and EL element using the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2008-01-15 US disclosed
WO-2007005289-A1 MONOMERS AND POLYMERS COMPRISING CONJUGATED GROUPS AND METHODS FOR MAKING THEREOF GENERAL ELECTRIC COMPANY (US) 2007-01-11 WO disclosed
US-20050256290-A1 Monomers and polymers comprising conjugated groups and methods for making thereof GENERAL ELECTRIC COMPANY 2005-11-17 US disclosed
US-20030091859-A1 Fluorene compounds containing various functional groups, polymers thereof and el element using the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2003-05-15 US disclosed
US-20020193522-A1 Synthesis and luminescent characteristics of novel phosphorus containing light-emitting polymers SUN YIH-MIN (TW) 2002-12-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12187934-B2 Thermally activated delayed fluorescence chromophores and organic layers including the same AR, NR0B2, NCOA2 NPC1 3542/4885RAB9A 2656/4885SMN1; SMN2 3755/4885
US-20250101295-A1 THERMALLY ACTIVATED DELAYED FLUORESCENCE CHROMOPHORES AND ORGANIC LAYERS INCLUDING THE SAME TBRG4, TRPA1, TYR NPC1 4818/4885RAB9A 4517/4885SMN1; SMN2 4647/4885
US-20030091859-A1 Fluorene compounds containing various functional groups, polymers thereof and el element using the same AFF4, AFF2, LEF1 NPC1 2346/4885RAB9A 1176/4885SMN1; SMN2 3299/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.