Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dexpramipexole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 1.00 |
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 1.00 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.97 |
| ▸ | HRH2 | P25021 | 2/20 | 0.95 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.95 |
| ▸ | HTR1A | P08908 | 1/20 | 0.95 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.95 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.95 |
| ▸ | HTR1B | P28222 | 1/20 | 0.95 |
| ▸ | HTR2A | P28223 | 1/20 | 0.95 |
| ▸ | HTR7 | P34969 | 1/20 | 0.95 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.95 |
| ▸ | HRH1 | P35367 | 1/20 | 0.95 |
| ▸ | HTR2B | P41595 | 1/20 | 0.95 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.95 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.95 |
| ▸ | SCN3A | Q9NY46 | 5/20 | 0.54 |
| ▸ | SCN4A | P35499 | 4/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pramipexole SCHEMBL22165339 | 1.00 | DRD3 (1.00) | DRD3DRD2DRD4ADRA2AHRH2 | |
| Pramipexole SCHEMBL28361114 | 1.00 | DRD3 (1.00) | DRD3DRD2DRD4ADRA2AHRH2 | |
| Pramipexole SCHEMBL3947282 | 1.00 | DRD3 (1.00) | DRD3DRD2DRD4ADRA2AHRH2 | |
| Pramipexole SCHEMBL28345162 | 1.00 | DRD3 (1.00) | DRD3DRD2DRD4ADRA2AHRH2 | |
| Pramipexole SCHEMBL2048695 | 1.00 | DRD3 (1.00) | DRD3DRD2DRD4ADRA2AHRH2 | |
| Pramipexole SCHEMBL153875 | 1.00 | DRD3 (1.00) | DRD3DRD2DRD4ADRA2AHRH2 | |
| Pramipexole SCHEMBL743891 | 1.00 | DRD3 (1.00) | DRD3DRD2DRD4ADRA2AHRH2 | |
| Pramipexole SCHEMBL28506481 | 1.00 | DRD3 (1.00) | DRD3DRD2DRD4ADRA2AHRH2 | |
| Dexpramipexole SCHEMBL910147 | 0.99 | ADRA2A (1.00) | DRD3DRD2DRD4ADRA2AHRH2 | |
| Pramipexole SCHEMBL20524815 | 0.99 | DRD3 (0.97) | DRD3DRD2DRD4ADRA2AHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 131 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3838271-B1 | TREATING ELEVATED LEVELS OF EOSINOPHILS AND/OR BASOPHILS | ARETEIA THERAPEUTICS INC (US) | 2025-09-03 | — | — | EP | claimed |
| US-20250213489-A1 | OSMOTIC TABLETS OF DEXPRAMIPEXOLE AND METHODS OF MANUFACTURING AND USE THEREOF | ARETEIA THERAPEUTICS, INC. (US) | 2025-07-03 | — | — | US | claimed |
| EP-4578509-A2 | TREATING ELEVATED LEVELS OF EOSINOPHILS AND/OR BASOPHILS | Areteia Therapeutics, Inc. (US) | 2025-07-02 | — | — | EP | claimed |
| WO-2025137498-A1 | MATRIX TABLETS OF DEXPRAMIPEXOLE AND METHODS OF MANUFACTURING AND USE THEREOF | ARETEIA THERAPEUTICS, INC. (US) | 2025-06-26 | — | — | WO | claimed |
| WO-2025137502-A1 | OSMOTIC TABLETS OF DEXPRAMIPEXOLE AND METHODS OF MANUFACTURING AND USE THEREOF | ARETEIA THERAPEUTICS, INC. (US) | 2025-06-26 | — | — | WO | claimed |
| US-20250205207-A1 | MATRIX TABLETS OF DEXPRAMIPEXOLE AND METHODS OF MANUFACTURING AND USE THEREOF | ARETEIA THERAPEUTICS, INC. (US) | 2025-06-26 | — | — | US | claimed |
| EP-4558622-A1 | METHODS AND COMPOSITIONS FOR GENERATING HUMAN MIDBRAIN DOPAMINERGIC NEURONS FROM NEURAL PROGENITOR CELLS | Trailhead Biosystems Inc. (US) | 2025-05-28 | — | — | EP | claimed |
| WO-2025088514-A1 | METTL3-METTL14-COMPLEX INHIBITORS FOR THE TREATMENT OF NEUROMUSCULAR DEGENERATIVE PATHOLOGIES CAUSED BY OR LINKED TO MUTATIONS IN THE FUS GENE | Università degli Studi di Roma “La Sapienza” (IT) | 2025-05-01 | — | — | WO | claimed |
| US-20240368293-A1 | Methods of Improving Recovery After Lung Resection | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2024-11-07 | — | — | US | claimed |
| US-20240117303-A1 | METHODS AND COMPOSITIONS FOR GENERATING HUMAN MIDBRAIN DOPAMINERGIC NEURONS FROM NEURAL PROGENITOR CELLS | TRAILHEAD BIOSYSTEMS INC. | 2024-04-11 | — | — | US | claimed |
| US-11026928-B2 | Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils | KNOPP BIOSCIENCES LLC (US) | 2021-06-08 | — | — | US | claimed |
| EP-3019167-B1 | TREATING ELEVATED LEVELS OF EOSINOPHILS AND/OR BASOPHILS | KNOPP BIOSCIENCES LLC (US) | 2021-02-17 | — | — | EP | claimed |
| US-10828284-B2 | Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils | KNOPP BIOSCIENCES LLC (US) | 2020-11-10 | — | — | US | claimed |
| US-10383857-B2 | Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils | KNOPP BIOSCIENCES LLC (US) | 2019-08-20 | — | — | US | claimed |
| US-20180271839-A1 | COMPOSITIONS AND METHODS FOR TREATING CONDITIONS RELATED TO ELEVATED LEVELS OF EOSINOPHILS AND/OR BASOPHILS | ARETEIA THERAPEUTICS, INC. | 2018-09-27 | — | — | US | claimed |
| US-20180110758-A1 | COMPOSITIONS AND METHODS OF USING (R)-PRAMIPEXOLE | KNOPP BIOSCIENCES LLC | 2018-04-26 | — | — | US | claimed |
| US-9849116-B2 | Compositions and methods of using (R)-pramipexole | KNOPP BIOSCIENCES LLC (US) | 2017-12-26 | — | — | US | claimed |
| US-20160158205-A1 | COMPOSITIONS AND METHODS FOR TREATING CONDITIONS RELATED TO ELEVATED LEVELS OF EOSINOPHILS AND/OR BASOPHILS | ARETEIA THERAPEUTICS, INC. | 2016-06-09 | — | — | US | claimed |
| US-20160030397-A1 | COMPOSITIONS AND METHODS OF USING (R)-PRAMIPEXOLE | ARETEIA THERAPEUTICS, INC. | 2016-02-04 | — | — | US | claimed |
| US-20110190356-A1 | Compositions and Methods of Using (R)- Pramipexole | KNOPP NEUROSCIENCES INC. (US) | 2011-08-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11026928-B2 | Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils | EPX, CMA1, CPA3 | DRD3 1954/4885DRD2 2140/4885DRD4 1893/4885 |
| US-20160030397-A1 | COMPOSITIONS AND METHODS OF USING (R)-PRAMIPEXOLE | HSPE1, GRIN2B, GRIN2A | DRD3 2160/4885DRD2 1622/4885DRD4 2604/4885 |
| US-10383857-B2 | Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils | EPX, CMA1, CPA3 | DRD3 1954/4885DRD2 2140/4885DRD4 1893/4885 |
| US-10828284-B2 | Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils | EPX, CMA1, CPA3 | DRD3 1954/4885DRD2 2140/4885DRD4 1893/4885 |
| US-20180271839-A1 | COMPOSITIONS AND METHODS FOR TREATING CONDITIONS RELATED TO ELEVATED LEVELS OF EOSINOPHILS AND/OR BASOPHILS | EPX, CMA1, CPA3 | DRD3 1954/4885DRD2 2140/4885DRD4 1893/4885 |
| US-20160158205-A1 | COMPOSITIONS AND METHODS FOR TREATING CONDITIONS RELATED TO ELEVATED LEVELS OF EOSINOPHILS AND/OR BASOPHILS | EPX, CMA1, CPA3 | DRD3 1954/4885DRD2 2140/4885DRD4 1893/4885 |
| US-20250205207-A1 | MATRIX TABLETS OF DEXPRAMIPEXOLE AND METHODS OF MANUFACTURING AND USE THEREOF | EPX, CMA1, CPA3 | DRD3 1370/4885DRD2 919/4885DRD4 839/4885 |
| US-20250213489-A1 | OSMOTIC TABLETS OF DEXPRAMIPEXOLE AND METHODS OF MANUFACTURING AND USE THEREOF | EPX, CMA1, TSLP | DRD3 990/4885DRD2 716/4885DRD4 629/4885 |
| US-20180110758-A1 | COMPOSITIONS AND METHODS OF USING (R)-PRAMIPEXOLE | HSPE1, GRIN2B, GRIN2A | DRD3 2160/4885DRD2 1622/4885DRD4 2604/4885 |
| US-20110190356-A1 | Compositions and Methods of Using (R)- Pramipexole | HSPE1, GRIN2B, GRIN2A | DRD3 2284/4885DRD2 1704/4885DRD4 2734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.