Flavokawain A

Flavokawain A

SCHEMBL2289181

COc1ccc(/C=C/C(=O)c2c(O)cc(OC)cc2OC)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 7/20 1.00
NFKB1 P19838 1/20 0.90
DPP4 P27487 1/20 0.90
NFKB2 Q00653 1/20 0.90
RELA Q04206 1/20 0.90
MAPT P10636 6/20 0.82
CYP3A4 P08684 6/20 0.82
KMT2A Q03164 5/20 0.82
TP53 P04637 2/20 0.82
ATM Q13315 1/20 0.82
HSD17B10 Q99714 1/20 0.82
MKNK2 Q9HBH9 1/20 0.81
MEN1 O00255 4/20 0.81
TDP1 Q9NUW8 3/20 0.81
KDM4E B2RXH2 2/20 0.81
HPGD P15428 2/20 0.81
MAPK1 P28482 2/20 0.81
MCL1 Q07820 1/20 0.81
USP2 O75604 1/20 0.81
ALDH1A1 P00352 1/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flavokawain A SCHEMBL25209870 1.00 ABCG2 (1.00) ABCG2NFKB1DPP4NFKB2RELA
Flavokawain A SCHEMBL29349587 1.00 ABCG2 (1.00) ABCG2NFKB1DPP4NFKB2RELA
Flavokawain A SCHEMBL2289188 1.00 ABCG2 (1.00) ABCG2NFKB1DPP4NFKB2RELA
Flavokawain C SCHEMBL30384247 0.94 NFKB1 (1.00) ABCG2NFKB1DPP4NFKB2RELA
Flavokawain C SCHEMBL25201341 0.94 NFKB1 (1.00) ABCG2NFKB1DPP4NFKB2RELA
Flavokawain C SCHEMBL144230 0.94 NFKB1 (1.00) ABCG2NFKB1DPP4NFKB2RELA
Flavokawain C SCHEMBL144231 0.94 NFKB1 (1.00) ABCG2NFKB1DPP4NFKB2RELA
SCHEMBL30383887 0.93 ABCG2 (0.87) ABCG2NFKB1DPP4NFKB2RELA
SCHEMBL2286230 0.93 ABCG2 (0.87) ABCG2NFKB1DPP4NFKB2RELA
SCHEMBL2286236 0.93 ABCG2 (0.87) ABCG2NFKB1DPP4NFKB2RELA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113956226-A Method for synthesizing carvachin 南京科技职业学院 2022-01-21 CN claimed
US-7326734-B2 Treatment of bladder and urinary tract cancers THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-02-05 US claimed
US-20040259813-A1 Treatment of bladder and urinary tract cancers THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2004-12-23 US claimed
US-20260048027-A1 METHYLATED PHLORETIN ANALOGS AS INHIBITORS OF SGLT2 NESTLE SA (CH) 2026-02-19 US disclosed
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
EP-4598515-A1 PHYTOCHEMICAL FORMULATIONS FOR TREATING STRESS AND ANXIETY GBS Global Biopharma, Inc. (CA) 2025-08-13 EP disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
US-20250090565-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YewSavin, Inc. (US) 2025-03-20 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
WO-2024054462-A1 PHYTOCHEMICAL FORMULATIONS FOR TREATING STRESS AND ANXIETY GBS GLOBAL BIOPHARMA, INC. (CA) 2024-03-14 WO disclosed
US-20070254859-A1 Compounds exhibiting efflux inhibitor activity and composition and uses thereof EASTMAN CHEMICAL COMPANY 2007-11-01 US disclosed
WO-2007115181-A2 COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF EASTMAN CHEMICAL COMPANY (US) 2007-10-11 WO disclosed
US-20040259813-A1 Treatment of bladder and urinary tract cancers THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2004-12-23 US disclosed
US-20040259813-A1 Treatment of bladder and urinary tract cancers THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2004-12-23 US disclosed
US-5234951-A Anti-ulcer agent comprising chalcone derivative TSUMURA JUNTENDO, INC. (JP) 1993-08-10 US disclosed
US-5106871-A Reduced side effects TSUMURA & CO. (JP) 1992-04-21 US disclosed
EP-0292576-A1 ANTI-ULCEROUS AGENT CONTAINING CHALCONE DERIVATIVE AS EFFECTIVE INGREDIENT AND NOVEL CHALCONE DERIVATIVES TSUMURA & CO. (JP) 1988-11-30 EP disclosed
US-4605674-A VIRICIDES HOFFMANN-LA ROCHE INC. (US) 1986-08-12 US disclosed
US-4327088-A ANTIVIRAL AGENTS HOFFMANN-LA ROCHE INC. (US) 1982-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254859-A1 Compounds exhibiting efflux inhibitor activity and composition and uses thereof ABCC4, NCOA4, NR4A3 ABCG2 5/4885NFKB1 1115/4885DPP4 1159/4885
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B ABCG2 1606/4885NFKB1 1669/4885DPP4 4226/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 ABCG2 3622/4885NFKB1 2437/4885DPP4 3670/4885
US-20260048027-A1 METHYLATED PHLORETIN ANALOGS AS INHIBITORS OF SGLT2 SLC5A2, SLC5A1, SLC2A1 ABCG2 954/4885NFKB1 4036/4885DPP4 302/4885
US-20040259813-A1 Treatment of bladder and urinary tract cancers KLK5, KLK4, KLK6 ABCG2 1850/4885NFKB1 2579/4885DPP4 2900/4885
US-20250090565-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, TFPI, SERPINE1 ABCG2 3458/4885NFKB1 2413/4885DPP4 3437/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.