SCHEMBL2286230

SCHEMBL2286230

COc1ccc(/C=C/C(=O)c2c(O)cc(O)cc2OC)cc1

nearest known ligand 0.87

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 7/20 0.87
TDP1 Q9NUW8 3/20 0.87
SLC5A1 P13866 2/20 0.84
SLC5A2 P31639 2/20 0.84
MAPT P10636 6/20 0.78
KMT2A Q03164 6/20 0.78
MEN1 O00255 5/20 0.78
NFKB1 P19838 1/20 0.78
DPP4 P27487 1/20 0.78
NFKB2 Q00653 1/20 0.78
RELA Q04206 1/20 0.78
KCNA3 P22001 1/20 0.78
NPSR1 Q6W5P4 1/20 0.78
CYP3A4 P08684 5/20 0.72
TP53 P04637 3/20 0.72
HSD17B10 Q99714 2/20 0.72
ATM Q13315 1/20 0.72
MKNK2 Q9HBH9 1/20 0.71
HPGD P15428 3/20 0.70
MAPK1 P28482 3/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30383887 1.00 ABCG2 (0.87) ABCG2TDP1SLC5A1SLC5A2MAPT
SCHEMBL2286236 1.00 ABCG2 (0.87) ABCG2TDP1SLC5A1SLC5A2MAPT
Flavokawain A SCHEMBL29349587 0.93 ABCG2 (1.00) ABCG2TDP1SLC5A1SLC5A2MAPT
Flavokawain A SCHEMBL2289188 0.93 ABCG2 (1.00) ABCG2TDP1SLC5A1SLC5A2MAPT
Flavokawain A SCHEMBL2289181 0.93 ABCG2 (1.00) ABCG2TDP1SLC5A1SLC5A2MAPT
Flavokawain A SCHEMBL25209870 0.93 ABCG2 (1.00) ABCG2TDP1SLC5A1SLC5A2MAPT
SCHEMBL4831536 0.93 TDP1 (1.00) ABCG2TDP1SLC5A1SLC5A2MAPT
SCHEMBL4831543 0.93 TDP1 (1.00) ABCG2TDP1SLC5A1SLC5A2MAPT
Helichrysetin SCHEMBL2126376 0.92 MAPT (0.82) ABCG2TDP1SLC5A1SLC5A2MAPT
Helichrysetin SCHEMBL2126372 0.92 MAPT (0.82) ABCG2TDP1SLC5A1SLC5A2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109890376-A Composition is used in PGC-1 α activation 三得利控股株式会社 2019-06-14 CN claimed
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed
CN-109890376-A Composition is used in PGC-1 α activation 三得利控股株式会社 2019-06-14 CN disclosed
US-9061984-B2 Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) 2015-06-23 US disclosed
US-9061984-B2 Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) 2015-06-23 US disclosed
US-9061984-B2 Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) 2015-06-23 US disclosed
US-20110190325-A1 COMPOUNDS, THEIR SYNTHESES, AND THIER USES THE JOHNS HOPKINS UNIVERSITY 2011-08-04 US disclosed
US-20110190325-A1 COMPOUNDS, THEIR SYNTHESES, AND THIER USES THE JOHNS HOPKINS UNIVERSITY 2011-08-04 US disclosed
US-20110190325-A1 COMPOUNDS, THEIR SYNTHESES, AND THIER USES THE JOHNS HOPKINS UNIVERSITY 2011-08-04 US disclosed
WO-2010019861-A1 COMPOUNDS, THEIR SYNTHESES, AND THEIR USES UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) 2010-02-18 WO disclosed
US-7326734-B2 Treatment of bladder and urinary tract cancers THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-02-05 US disclosed
US-20040259813-A1 Treatment of bladder and urinary tract cancers THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2004-12-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B ABCG2 1606/4885TDP1 3071/4885SLC5A1 3752/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 ABCG2 3622/4885TDP1 3151/4885SLC5A1 4485/4885
US-20110190325-A1 COMPOUNDS, THEIR SYNTHESES, AND THIER USES TERT, TYMS, NISCH ABCG2 1032/4885TDP1 2214/4885SLC5A1 1429/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 ABCG2 3622/4885TDP1 3151/4885SLC5A1 4485/4885
US-20040259813-A1 Treatment of bladder and urinary tract cancers KLK5, KLK4, KLK6 ABCG2 1850/4885TDP1 2857/4885SLC5A1 1760/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.