Flavokawain C

Flavokawain C

SCHEMBL144230

COc1cc(O)c(C(=O)/C=C/c2ccc(O)cc2)c(OC)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 1/20 1.00
DPP4 P27487 1/20 1.00
NFKB2 Q00653 1/20 1.00
RELA Q04206 1/20 1.00
ABCG2 Q9UNQ0 6/20 0.90
MAPT P10636 5/20 0.82
CYP3A4 P08684 4/20 0.82
KMT2A Q03164 4/20 0.82
TP53 P04637 2/20 0.82
ATM Q13315 1/20 0.82
HSD17B10 Q99714 1/20 0.82
MKNK2 Q9HBH9 1/20 0.81
TDP1 Q9NUW8 3/20 0.81
MEN1 O00255 3/20 0.81
KDM4E B2RXH2 2/20 0.81
HPGD P15428 2/20 0.81
MCL1 Q07820 1/20 0.81
USP2 O75604 1/20 0.81
ALDH1A1 P00352 1/20 0.81
ALOX15 P16050 1/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flavokawain C SCHEMBL30384247 1.00 NFKB1 (1.00) NFKB1DPP4NFKB2RELAABCG2
Flavokawain C SCHEMBL144231 1.00 NFKB1 (1.00) NFKB1DPP4NFKB2RELAABCG2
Flavokawain C SCHEMBL25201341 1.00 NFKB1 (1.00) NFKB1DPP4NFKB2RELAABCG2
Flavokawain C SCHEMBL25206856 0.99 NFKB1 (0.97) NFKB1DPP4NFKB2RELAABCG2
Flavokawain A SCHEMBL2289181 0.94 ABCG2 (1.00) NFKB1DPP4NFKB2RELAABCG2
Flavokawain A SCHEMBL2289188 0.94 ABCG2 (1.00) NFKB1DPP4NFKB2RELAABCG2
Flavokawain A SCHEMBL29349587 0.94 ABCG2 (1.00) NFKB1DPP4NFKB2RELAABCG2
Flavokawain A SCHEMBL25209870 0.94 ABCG2 (1.00) NFKB1DPP4NFKB2RELAABCG2
SCHEMBL25200484 0.94 NFKB1 (0.89) NFKB1DPP4NFKB2RELAABCG2
SCHEMBL633183 0.94 NFKB1 (0.89) NFKB1DPP4NFKB2RELAABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4229639-A1 METHOD AND SYSTEMS FOR PHYTOMEDICINE ANALYTICS FOR RESEARCH OPTIMIZATION AT SCALE GBS Global Biopharma, Inc. (CA) 2023-08-23 EP claimed
WO-2022081889-A1 METHOD AND SYSTEMS FOR PHYTOMEDICINE ANALYTICS FOR RESEARCH OPTIMIZATION AT SCALE GBS GLOBAL BIOPHARMA, INC. (CA) 2022-04-21 WO claimed
US-20190046469-A1 COMPOSITIONS AND METHODS FOR TREATING MOOD DISORDERS OR SKIN DISEASE OR DAMAGE KUHRTS ERIC HAUSER (US) 2019-02-14 US claimed
US-20150209307-A1 COMPOSITIONS AND METHODS FOR TREATING MOOD DISORDERS OR SKIN DISEASE OR DAMAGE KUHRTS ERIC HAUSER (US) 2015-07-30 US claimed
WO-2014025989-A1 COMPOSITIONS AND METHODS FOR TREATING MOOD DISORDERS OR SKIN DISEASE OR DAMAGE KUHRTS ERIC HAUSER (US) 2014-02-13 WO claimed
US-20140045904-A1 NIACIN FORMULATIONS AND METHODS WITH REDUCED FLUSHING SIDE EFFECT KUHRTS ERIC HAUSER (US) 2014-02-13 US claimed
WO-2012051107-A2 NIACIN FORMULATIONS AND METHODS WITH REDUCED FLUSHING SIDE-EFFECT KUHRTS ERIC HAUSER (US) 2012-04-19 WO claimed
US-20120059052-A1 PRENYLFLAVONOID FORMULATIONS BIOACTIVES, INC. (US) 2012-03-08 US claimed
US-20110003888-A1 HOPS EXTRACTION METHODS AND MIXTURES BIOACTIVES, INC. (US) 2011-01-06 US claimed
US-20090209654-A1 Prenylflavonoid Formulations BIOACTIVES, INC. 2009-08-20 US claimed
WO-2008095189-A1 METHODS AND COMPOSITIONS FOR TREATING DYSLIPIDAEMIA BIOACTIVES, INC. (US) 2008-08-07 WO claimed
WO-2008089137-A1 HOPS EXTRACTION METHODS AND MIXTURES BIOACTIVES, INC. (US) 2008-07-24 WO claimed
EP-1909584-A2 PRENYLFLAVONOID FORMULATIONS Bioactives, Inc. (US) 2008-04-16 EP claimed
US-20070218155-A1 Methods and compositions for treating dyslipidaemia BIOACTIVES, INC. 2007-09-20 US claimed
WO-2007016578-A2 PRENYLFLAVONOID FORMULATIONS BIOACTIVES, INC. (US) 2007-02-08 WO claimed
WO-2026102866-A1 USE OF COMBINATION OF FGF-2 AND FLAVOKAWAIN C IN PREPARATION OF DRUG FOR TREATING UTERINE ADHESIONS 温州医科大学 2026-05-21 WO disclosed
EP-4734923-A1 CLEANSING COMPOSITIONS COMPRISING DIVALENT SALTS L'OREAL (FR) 2026-05-06 EP disclosed
EP-1175425-A2 INHIBITORS OF INTESTINAL APICAL MEMBRANE NA/PHOSPHATE CO-TRANSPORTATION THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2002-01-30 EP disclosed
WO-2000043402-A2 INHIBITORS OF INTESTINAL APICAL MEMBRANE NA/PHOSPHATE CO-TRANSPORTATION BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2000-07-27 WO disclosed
US-4327088-A ANTIVIRAL AGENTS HOFFMANN-LA ROCHE INC. (US) 1982-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120059052-A1 PRENYLFLAVONOID FORMULATIONS TP53, CYP46A1, HPGD NFKB1 590/4885DPP4 3400/4885NFKB2 294/4885
US-20150209307-A1 COMPOSITIONS AND METHODS FOR TREATING MOOD DISORDERS OR SKIN DISEASE OR DAMAGE CUTA, PSEN2, PNN NFKB1 2139/4885DPP4 4002/4885NFKB2 2025/4885
US-20190046469-A1 COMPOSITIONS AND METHODS FOR TREATING MOOD DISORDERS OR SKIN DISEASE OR DAMAGE CUTA, PSEN2, PNN NFKB1 2139/4885DPP4 4002/4885NFKB2 2025/4885
US-20110003888-A1 HOPS EXTRACTION METHODS AND MIXTURES HMGB2, HMGB3, HPGDS NFKB1 2092/4885DPP4 2700/4885NFKB2 2036/4885
US-20140045904-A1 NIACIN FORMULATIONS AND METHODS WITH REDUCED FLUSHING SIDE EFFECT NAPRT, NISCH, NAMPT NFKB1 1888/4885DPP4 2758/4885NFKB2 2802/4885
US-20090209654-A1 Prenylflavonoid Formulations TP53, CYP46A1, HPGD NFKB1 590/4885DPP4 3400/4885NFKB2 294/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.