Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.46 |
| ▸ | CDK9 | P50750 | 7/20 | 0.46 |
| ▸ | CDK7 | P50613 | 7/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.46 |
| ▸ | CCNH | P51946 | 5/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.46 |
| ▸ | CDK4 | P11802 | 4/20 | 0.46 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | CCND1 | P24385 | 3/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.46 |
| ▸ | CDK3 | Q00526 | 2/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL33377999 | 0.86 | CSNK2B (0.60) | CDK2CDK9CDK7CCNT1CCNH | |
| SCHEMBL31064144 | 0.85 | CDK2 (0.43) | CDK2CDK9CDK7CCNT1CCNH | |
| SCHEMBL22449329 | 0.84 | CDK9 (0.49) | CDK2CDK9CDK7CCNT1CCNH | |
| SCHEMBL14427510 | 0.83 | CDK2 (0.44) | CDK2CDK9CDK7CCNT1CCNH | |
| SCHEMBL28551273 | 0.83 | CDK7 (0.43) | CDK2CDK9CDK7CCNT1CCNH | |
| SCHEMBL22899498 | 0.83 | RAB9A (0.51) | CDK2CDK9CDK7CCNT1CCNH | |
| SCHEMBL24174228 | 0.82 | CDK2 (0.50) | CDK2CDK9CDK7CCNT1CCNH | |
| SCHEMBL18309940 | 0.80 | LMNA (0.41) | CDK2CDK9CDK7CCNHCCNE1 | |
| SCHEMBL14427502 | 0.79 | ALDH1A1 (0.53) | CDK2CDK9CDK7CCNT1CDK4 | |
| SCHEMBL21481514 | 0.78 | CDK2 (0.36) | CDK2CDK9CDK7CCNT1CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011689-A1 | CD73 INHIBITORS | ORIC PHARMACEUTICALS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |