Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 5/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22902719 | 0.85 | JAK1 (0.40) | JAK1JAK2KMT2AL3MBTL1RET | |
| SCHEMBL22902683 | 0.82 | JAK1 (0.38) | JAK1JAK2KMT2AL3MBTL1RET | |
| SCHEMBL22902495 | 0.82 | PIK3R1 (0.38) | JAK1JAK2PIK3CAPIK3R1BUB1 | |
| SCHEMBL24590579 | 0.79 | KDM4E (0.37) | JAK1RETKDRPIK3CA | |
| SCHEMBL29737131 | 0.79 | KDM4E (0.37) | JAK1RETKDRPIK3CA | |
| SCHEMBL18644666 | 0.78 | SRC (0.45) | PIK3CA | |
| SCHEMBL22902468 | 0.78 | L3MBTL1 (0.39) | JAK1JAK2KMT2AL3MBTL1EPHX2 | |
| SCHEMBL30111813 | 0.77 | BTK (0.46) | JAK1JAK2PIK3CA | |
| SCHEMBL23450731 | 0.77 | BTK (0.46) | JAK1JAK2PIK3CA | |
| SCHEMBL22605489 | 0.76 | ALDH1A1 (0.50) | KMT2AL3MBTL1EPHX2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011428-A1 | HETEROCYCLIC KINASE INHIBITORS | GB005, INC. (US) | 2021-01-21 | — | — | WO | disclosed |