Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 6/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22902720 | 0.83 | ALDH1A1 (0.34) | PIK3R1PIK3CABUB1SPRPDE10A | |
| SCHEMBL22902497 | 0.83 | ALDH1A1 (0.34) | PIK3R1PIK3CABUB1SPRPDE10A | |
| SCHEMBL22902469 | 0.82 | JAK1 (0.41) | PIK3R1PIK3CAAURKAPDPK1AURKB | |
| SCHEMBL22902459 | 0.79 | OPRM1 (0.35) | BUB1 | |
| SCHEMBL24590579 | 0.77 | KDM4E (0.37) | PIK3CASPRJAK1 | |
| SCHEMBL29737131 | 0.77 | KDM4E (0.37) | PIK3CASPRJAK1 | |
| SCHEMBL18644666 | 0.77 | SRC (0.45) | PIK3CA | |
| SCHEMBL30111813 | 0.75 | BTK (0.46) | PIK3CAJAK1JAK2 | |
| SCHEMBL23450731 | 0.75 | BTK (0.46) | PIK3CAJAK1JAK2 | |
| SCHEMBL18289974 | 0.75 | BTK (0.46) | PIK3CAJAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011428-A1 | HETEROCYCLIC KINASE INHIBITORS | GB005, INC. (US) | 2021-01-21 | — | — | WO | disclosed |