Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | TDO2 | P48775 | 2/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11638383 | 0.75 | ADORA2A (0.49) | ALDH1A1LMNAIDO1TDO2MAPT | |
| SCHEMBL11639056 | 0.72 | ADORA2A (0.47) | ALDH1A1LMNAIDO1TDO2MAPT | |
| SCHEMBL9219418 | 0.70 | TSHR (0.40) | ALDH1A1LMNAMAPTKDM4EHPGD | |
| SCHEMBL22904142 | 0.69 | MEN1 (0.46) | ALDH1A1LMNAIDO1MAPTKDM4E | |
| SCHEMBL9043662 | 0.69 | ALDH1A1 (0.53) | ALDH1A1LMNAIDO1TDO2CES1 | |
| SCHEMBL17338762 | 0.68 | AADAT (0.47) | ALDH1A1LMNAIDO1MAPTKDM4E | |
| SCHEMBL9220188 | 0.68 | AADAT (0.47) | ALDH1A1LMNAMAPTKDM4EHPGD | |
| SCHEMBL44496 | 0.67 | CES1 (0.90) | ALDH1A1CES1MAPTKMT2AMEN1 | |
| SCHEMBL29408351 | 0.67 | CES1 (0.90) | ALDH1A1CES1MAPTKMT2AMEN1 | |
| SCHEMBL29437756 | 0.67 | CES1 (0.90) | ALDH1A1CES1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0339978-B1 | Fused polycyclic compounds, compositions, methods of manufacture, and their use as PAF antagonists, antihistamines and/or antiinflammatory agents | SCHERING CORP (US) | 1996-08-21 | — | — | EP | disclosed |
| EP-0412988-A1 | FUSED POLYCYCLIC COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE AND THEIR USE AS PAF ANTAGONISTS, ANTIHISTAMINES AND/OR ANTIINFLAMMATORY AGENTS | SCHERING CORPORATION (US) | 1991-02-20 | — | — | EP | disclosed |
| EP-0339978-A1 | Fused polycyclic compounds, compositions, methods of manufacture, and their use as PAF antagonists, antihistamines and/or antiinflammatory agents | SCHERING CORPORATION (US) | 1989-11-02 | — | — | EP | disclosed |
| WO-1989010363-A1 | FUSED POLYCYCLIC COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE AND THEIR USE AS PAF ANTAGONISTS, ANTIHISTAMINES AND/OR ANTIINFLAMMATORY AGENTS | SCHERING CORPORATION (US) | 1989-11-02 | — | — | WO | disclosed |