Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904557 | 0.79 | HTR1A (0.51) | HTR1AADRA1AADRA1BNPC1MAPK1 | |
| SCHEMBL22904352 | 0.75 | CYP3A4 (0.49) | MAPK1GAAMEN1KMT2ATP53 | |
| SCHEMBL10112002 | 0.74 | HTR1A (0.47) | HTR1AADRA1AADRA1BFFAR1FFAR4 | |
| SCHEMBL17542688 | 0.73 | SMN1; SMN2 (0.41) | P2RX7NPC1GAAMEN1CASP6 | |
| SCHEMBL30952449 | 0.72 | ADRB1 (0.56) | HTR1ADRD2KDRALDH1A1 | |
| SCHEMBL231592 | 0.72 | ADRB1 (0.56) | HTR1ADRD2KDRALDH1A1 | |
| SCHEMBL20103179 | 0.71 | HTR1A (0.48) | HTR1AADRA1AADRA1BADRA1DP2RX7 | |
| SCHEMBL22904468 | 0.71 | P2RX7 (0.42) | P2RX7GAAMEN1CASP6KMT2A | |
| SCHEMBL22904456 | 0.71 | HTR1A (0.55) | HTR1AADRA1BMEN1KMT2ALMNA | |
| SCHEMBL22246115 | 0.71 | ALDH1A1 (0.57) | HTR1AADRA1AADRA1BADRA1DGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |