Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.43 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.43 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26847910 | 0.93 | ITGB3 (0.49) | ITGB3ITGA2BITGA2ABHD6THRB | |
| SCHEMBL24207225 | 0.92 | ALOX15 (0.38) | THRBGAAKDM4EALOX15POLB | |
| SCHEMBL24421185 | 0.88 | ITGB3 (0.35) | ITGB3ITGA2BITGA2THRBGAA | |
| SCHEMBL23984162 | 0.88 | ITGB3 (0.39) | ITGB3ITGA2BITGA2THRBGAA | |
| SCHEMBL21983039 | 0.87 | ITGB3 (0.39) | ITGB3ITGA2BITGA2ABHD6KDM4E | |
| SCHEMBL21480827 | 0.87 | ITGB3 (0.39) | ITGB3ITGA2BITGA2ABHD6KDM4E | |
| SCHEMBL23983490 | 0.87 | ITGB3 (0.36) | ITGB3ITGA2BTHRBGAAKDM4E | |
| SCHEMBL20231892 | 0.87 | ITGB3 (0.41) | ITGB3ITGA2BITGA2ABHD6THRB | |
| SCHEMBL24421199 | 0.86 | THRB (0.36) | THRBGAAKDM4EALOX15POLB | |
| SCHEMBL22907292 | 0.85 | THRB (0.33) | THRBGAAKDM4EALOX15POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011913-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |