Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SDCBP | O00560 | 1/20 | 0.32 |
| ▸ | SDC2 | P34741 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24207225 | 0.88 | ALOX15 (0.38) | THRBGAAPOLBKDM4EALOX15 | |
| SCHEMBL22906777 | 0.85 | ITGB3 (0.43) | THRBGAAPOLBKDM4EALOX15 | |
| SCHEMBL23983490 | 0.83 | ITGB3 (0.36) | THRBGAAPOLBKDM4EALOX15 | |
| SCHEMBL24421185 | 0.83 | ITGB3 (0.35) | THRBGAAPOLBKDM4EALOX15 | |
| SCHEMBL24678167 | 0.83 | LMNA (0.34) | THRBGAAPOLBKDM4EALOX15 | |
| SCHEMBL23984162 | 0.82 | ITGB3 (0.39) | THRBGAAPOLBKDM4EALOX15 | |
| SCHEMBL24421199 | 0.82 | THRB (0.36) | THRBGAAPOLBKDM4EALOX15 | |
| SCHEMBL27271167 | 0.80 | LMNA (0.37) | THRBGAAPOLBKDM4EALOX15 | |
| SCHEMBL27370457 | 0.79 | CNR1 (0.39) | MAPTALDH1A1LMNA | |
| SCHEMBL25032020 | 0.78 | ALOX15 (0.40) | THRBGAAPOLBKDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011913-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |