Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.39 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23983490 | 0.90 | ITGB3 (0.36) | ITGB3ITGA2BITGB1ITGAVITGA5 | |
| SCHEMBL24207225 | 0.90 | ALOX15 (0.38) | THRBGAAKDM4EALOX15POLB | |
| SCHEMBL22906777 | 0.88 | ITGB3 (0.43) | ITGB3ITGA2BTHRBGAAKDM4E | |
| SCHEMBL27271167 | 0.87 | LMNA (0.37) | ITGB3ITGA2BITGB1ITGAVITGA5 | |
| SCHEMBL24421185 | 0.86 | ITGB3 (0.35) | ITGB3ITGA2BITGB1ITGAVITGA5 | |
| SCHEMBL24421199 | 0.85 | THRB (0.36) | THRBGAAKDM4EALOX15POLB | |
| SCHEMBL27370457 | 0.83 | CNR1 (0.39) | LMNAMAPTSYKALDH1A1 | |
| SCHEMBL24421384 | 0.83 | ITGB3 (0.37) | ITGB3ITGA2BITGB1ITGAVITGA5 | |
| SCHEMBL22907292 | 0.82 | THRB (0.33) | THRBGAAKDM4EALOX15POLB | |
| SCHEMBL26847910 | 0.81 | ITGB3 (0.49) | ITGB3ITGA2BTHRBGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021219070-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2021-11-04 | — | — | WO | disclosed |