Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARK7 | Q99497 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22912916 | 0.86 | MEN1 (0.45) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL5076661 | 0.83 | ADORA3 (0.40) | MEN1KMT2AMAPTLMNACYP19A1 | |
| SCHEMBL22913779 | 0.80 | PTGS1 (0.43) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL25592835 | 0.79 | MEN1 (0.45) | PARK7MEN1KMT2ANPC1RAB9A | |
| SCHEMBL23448677 | 0.78 | AADAT (0.42) | PARK7MEN1KMT2ANPC1RAB9A | |
| SCHEMBL22912929 | 0.78 | MAPT (0.40) | PARK7MEN1KMT2ANPC1RAB9A | |
| SCHEMBL17385333 | 0.77 | MEN1 (0.45) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL662061 | 0.75 | IDO1 (0.45) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL16617214 | 0.75 | NPC1 (0.36) | NPC1RAB9AMAPTMAT2ALMNA | |
| SCHEMBL27331396 | 0.75 | ADRB2 (0.40) | PARK7MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114929683-B | Pyridine derivatives as modulators of calcium activated chloride channels | 跨膜蛋白16A有限公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-114929683-A | Pyridine derivatives as calcium-activated chloride channel modulators | 跨膜蛋白16A有限公司 | 2022-08-19 | — | — | CN | disclosed |
| EP-4003977-A1 | PYRIDINE DERIVATIVES AS CALCIUM-ACTIVATED CHLORIDE CHANNEL MODULATORS | TMEM16A LIMITED (GB) | 2022-06-01 | — | — | EP | disclosed |
| WO-2021014172-A1 | PYRIDINE DERIVATIVES AS CALCIUM-ACTIVATED CHLORIDE CHANNEL MODULATORS | Enterprise Therapeutics Limited (GB) | 2021-01-28 | — | — | WO | disclosed |