Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22912916 | 0.81 | MEN1 (0.45) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL22912925 | 0.80 | PARK7 (0.41) | KDM4ELMNAKMT2AMEN1NPC1 | |
| SCHEMBL22913544 | 0.79 | CACNA1G (0.43) | PTGS1AKR1C3AKR1C2KDM4ELMNA | |
| SCHEMBL27786370 | 0.77 | CACNA1G (0.46) | LMNACACNA1GCACNA1HCACNA1IADORA3 | |
| SCHEMBL22913774 | 0.76 | PDE1A (0.50) | PTGS1AKR1C3AKR1C2KDM4ELMNA | |
| SCHEMBL23448671 | 0.74 | PTGER4 (0.44) | CACNA1GCACNA1HCACNA1IPOLBADORA3 | |
| SCHEMBL3125465 | 0.72 | KMT2A (0.53) | KDM4ELMNABLMCACNA1GCACNA1H | |
| SCHEMBL23448681 | 0.71 | ALDH1A1 (0.47) | KDM4ECYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7977921 | 0.70 | KDM4E (0.50) | KDM4ECYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL23833395 | 0.70 | CACNA1G (0.58) | PTGS1AKR1C3AKR1C2KDM4ECACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114929683-B | Pyridine derivatives as modulators of calcium activated chloride channels | 跨膜蛋白16A有限公司 | 2024-09-03 | — | — | CN | disclosed |
| US-20220144803-A1 | PYRIDINE DERIVATIVES AS CALCIUM-ACTIVATED CHLORIDE CHANNEL MODULATORS | Enterprise Therapeutics Limited (GB) | 2022-05-12 | — | — | US | disclosed |
| WO-2021014172-A1 | PYRIDINE DERIVATIVES AS CALCIUM-ACTIVATED CHLORIDE CHANNEL MODULATORS | Enterprise Therapeutics Limited (GB) | 2021-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220144803-A1 | PYRIDINE DERIVATIVES AS CALCIUM-ACTIVATED CHLORIDE CHANNEL MODULATORS | TMEM109, CACNA1E, CACNA1A | PTGS1 1252/4885AKR1C3 2030/4885AKR1C2 2400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.