SCHEMBL2291603

SCHEMBL2291603

Cc1ccc(C#N)nc1Cl

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.39
NQO1 P15559 1/20 0.38
EGLN2 Q96KS0 3/20 0.36
SOS2 Q07890 1/20 0.36
KDM4E B2RXH2 2/20 0.35
CYP1A2 P05177 2/20 0.35
CYP2C9 P11712 2/20 0.35
CYP2C19 P33261 2/20 0.35
NPSR1 Q6W5P4 1/20 0.35
KMT2A Q03164 3/20 0.33
MEN1 O00255 2/20 0.32
TSHR P16473 2/20 0.32
CTSK P43235 1/20 0.32
GLA P06280 1/20 0.32
HTT P42858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31236717 0.86 ALDH1A1 (0.41) ALDH1A1L3MBTL1NQO1EGLN2SOS2
SCHEMBL7846050 0.77 SOS2 (0.38) ALDH1A1NQO1EGLN2SOS2KDM4E
SCHEMBL701812 0.77 NOS3 (0.44) ALDH1A1NQO1EGLN2SOS2KDM4E
SCHEMBL21928126 0.76 NQO1 (0.39) ALDH1A1NQO1EGLN2SOS2KDM4E
SCHEMBL25268051 0.74 KHK (0.36) ALDH1A1NQO1EGLN2SOS2KDM4E
SCHEMBL16372364 0.74 SOS2 (0.48) ALDH1A1NQO1EGLN2SOS2KDM4E
SCHEMBL11916709 0.74 SOS2 (0.36) ALDH1A1L3MBTL1NQO1EGLN2SOS2
SCHEMBL2981097 0.74 NQO1 (0.38) ALDH1A1NQO1EGLN2SOS2KDM4E
SCHEMBL16834623 0.74 SOS2 (0.44) ALDH1A1NQO1EGLN2SOS2KDM4E
SCHEMBL29560656 0.74 NQO1 (0.38) ALDH1A1NQO1EGLN2SOS2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260146047-A1 MACROCYCLIC HETEROCYCLE COMPOUNDS AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2026-05-28 US disclosed
EP-3898646-B1 3.ALPHA.-HYDROXY-17.BETA.-AMIDE NEUROACTIVE STEROIDS AND COMPOSITIONS THEREOF SAGE THERAPEUTICS LLC (US) 2026-02-18 EP disclosed
EP-4680611-A1 MACROCYCLIC HETEROCYCLE COMPOUNDS AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2026-01-21 EP disclosed
WO-2024189597-A1 MACROCYCLIC HETEROCYCLE COMPOUNDS AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2024-09-19 WO disclosed
US-20240309016-A1 MACROCYCLIC HETEROCYCLE COMPOUNDS AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2024-09-19 US disclosed
WO-2024009232-A1 SUBSTITUTED N-(PYRIDIN-2-YL)ACETAMIDE DERIVATIVES AS CDK12/13 INHIBITORS AURIGENE ONCOLOGY LIMITED (IN) 2024-01-11 WO disclosed
US-20220372067-A1 3.ALPHA.-HYDROXY-17.BETA.-AMIDE NEUROACTIVE STEROIDS AND COMPOSITIONS THEREOF SAGE THERAPEUTICS, INC. 2022-11-24 US disclosed
WO-2020132504-A1 3.ALPHA.-HYDROXY-17.BETA.-AMIDE NEUROACTIVE STEROIDS AND COMPOSITIONS THEREOF SAGE THERAPEUTICS, INC. (US) 2020-06-25 WO disclosed
US-20190224190-A1 PYRIDINYL AND FUSED PYRIDINYL TRIAZOLONE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2019-07-25 US disclosed
US-10307414-B2 Pyridinyl and fused pyridinyl triazolone derivatives TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2019-06-04 US disclosed
US-20100190775-A1 PYRIMIDODIAZEPINONE DERIVATIVE KYOWA HAKKO KIRIN CO., LTD (JP) 2010-07-29 US disclosed
EP-2172465-A1 2-(pyridin -2-yl)-pyrimidines and their use for controlling pathogenic fungi BASF SE (DE) 2010-04-07 EP disclosed
EP-2172466-A1 2-(pyridin-2-yl)-pyrimidines and use of same to combat hazardous fungi BASF SE (DE) 2010-04-07 EP disclosed
EP-2172467-A1 2-(pyridin -2-yl)-pyrimidines and their use for controlling pathogenic fungi BASF SE (DE) 2010-04-07 EP disclosed
EP-2163554-A1 PYRIMIDODIAZEPINONE DERIVATIVE Kyowa Hakko Kirin Co., Ltd. (JP) 2010-03-17 EP disclosed
EP-1773806-B1 2-(PYRIDIN-2-YL)-PYRIMIDINES AND THEIR USE FOR CONTROLLING PATHOGENIC FUNGI BASF SE (DE) 2010-02-24 EP disclosed
US-20080027085-A1 2-(Pyridin-2-Yl)-Pyrimidines and Their Use for Controlling Harmful Fungi BASF AKTIENGESELLSCHAFT (DE) 2008-01-31 US disclosed
CN-1989125-A 2-(pyridin-2-yl)-pyrimidines and their use for controlling pathogenic fungi BASF AG (DE) 2007-06-27 CN disclosed
EP-1773806-A1 2-(PYRIDIN-2-YL)-PYRIMIDINES AND THEIR USE FOR CONTROLLING PATHOGENIC FUNGI BASF AKTIENGESELLSCHAFT (DE) 2007-04-18 EP disclosed
WO-2006010570-A1 2-(PYRIDIN-2-YL)-PYRIMIDINES AND THEIR USE FOR CONTROLLING PATHOGENIC FUNGI BASF AKTIENGESELLSCHAFT (DE) 2006-02-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220372067-A1 3.ALPHA.-HYDROXY-17.BETA.-AMIDE NEUROACTIVE STEROIDS AND COMPOSITIONS THEREOF HSD17B7, HSD3B1, HSD17B3 ALDH1A1 651/4885L3MBTL1 3934/4885NQO1 1587/4885
US-20080027085-A1 2-(Pyridin-2-Yl)-Pyrimidines and Their Use for Controlling Harmful Fungi CBR1, CBR3, CNPY2 ALDH1A1 1007/4885L3MBTL1 789/4885NQO1 448/4885
US-20100190775-A1 PYRIMIDODIAZEPINONE DERIVATIVE KCNJ1, KCNJ11, ADRA1D ALDH1A1 407/4885L3MBTL1 2932/4885NQO1 959/4885
US-20190224190-A1 PYRIDINYL AND FUSED PYRIDINYL TRIAZOLONE DERIVATIVES BTK, LCK, TYK2 ALDH1A1 2160/4885L3MBTL1 2331/4885NQO1 1544/4885
US-20240309016-A1 MACROCYCLIC HETEROCYCLE COMPOUNDS AND USE THEREOF HCRTR2, HCRTR1, NTSR2 ALDH1A1 2526/4885L3MBTL1 3574/4885NQO1 1483/4885
US-20260146047-A1 MACROCYCLIC HETEROCYCLE COMPOUNDS AND USE THEREOF HCRTR2, HCRTR1, NPY1R ALDH1A1 3220/4885L3MBTL1 857/4885NQO1 3918/4885
US-10307414-B2 Pyridinyl and fused pyridinyl triazolone derivatives BTK, LCK, TYK2 ALDH1A1 2160/4885L3MBTL1 2331/4885NQO1 1544/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.