Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018079 | 0.83 | TSHR (0.53) | ALDH1A1NPC1RAB9ASRD5A2PDK1 | |
| SCHEMBL27904103 | 0.83 | SRD5A2 (0.64) | ALDH1A1NPC1RAB9AMAPK13MAPK12 | |
| SCHEMBL3787476 | 0.83 | ALDH1A1 (0.51) | ALDH1A1NPC1RAB9AMAPTPDK1 | |
| SCHEMBL28714550 | 0.82 | KDM4E (0.68) | ALDH1A1RAB9AMAPK13MAPK12MAPK11 | |
| SCHEMBL28719962 | 0.80 | KDM4E (0.66) | ALDH1A1RAB9AMAPK13MAPK12MAPK11 | |
| SCHEMBL5068843 | 0.79 | SRD5A2 (0.68) | ALDH1A1RAB9AMAPK13MAPK12MAPK11 | |
| SCHEMBL22927642 | 0.78 | TSHR (0.55) | ALDH1A1NPC1RAB9AMAPK13MAPK12 | |
| SCHEMBL29434760 | 0.78 | SRD5A2 (0.53) | ALDH1A1RAB9AMAPK13MAPK12MAPK11 | |
| SCHEMBL11233382 | 0.77 | HPGD (0.64) | ALDH1A1NPC1RAB9AMAPK13MAPK12 | |
| SCHEMBL10946377 | 0.77 | SRD5A2 (0.49) | ALDH1A1RAB9AMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220289728-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS INC (US) | 2022-09-15 | — | — | US | disclosed |
| EP-4003985-A1 | MODULATORS OF TREX1 | Constellation Pharmaceuticals, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |
| CN-114174290-A | Modulators of TREX1 | 星座制药公司 | 2022-03-11 | — | — | CN | disclosed |
| WO-2021016317-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2021-01-28 | — | — | WO | disclosed |
| WO-2021016317-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2021-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220289728-A1 | MODULATORS OF TREX1 | CFTR, SLC10A1, CYP27A1 | ALDH1A1 693/4885NPC1 4/4885RAB9A 1079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.