Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.44 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL229621 | 0.98 | BCL2 (0.48) | BCL2BCL2L1CALM1IDH1CHUK | |
| SCHEMBL9321232 | 0.86 | BCL2 (0.42) | BCL2BCL2L1CALM1IDH1CHUK | |
| SCHEMBL2614741 | 0.79 | CALM1 (0.61) | CALM1CHUKTXNRD1NOX4ALDH1A1 | |
| SCHEMBL2118698 | 0.79 | CYP17A1 (0.46) | ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2117868 | 0.77 | ALOX5 (0.46) | ALDH1A1MEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL13729492 | 0.77 | CALM1 (0.46) | BCL2BCL2L1CALM1IDH1CHUK | |
| SCHEMBL2116081 | 0.76 | MMP1 (0.47) | ALDH1A1MEN1KMT2AL3MBTL1TSHR | |
| SCHEMBL8443402 | 0.76 | CHUK (0.41) | BCL2BCL2L1CALM1IDH1CHUK | |
| SCHEMBL27936593 | 0.74 | CALM1 (0.48) | CALM1CHUKTXNRD1NOX4ALDH1A1 | |
| SCHEMBL631807 | 0.72 | ALDH1A1 (0.47) | CALM1ALDH1A1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324228-B2 | Pyrimidine classical cannabinoid compounds and related methods of use | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2012-12-04 | — | — | US | disclosed |
| US-20120004250-A1 | PYRIMIDINE CLASSICAL CANNABINOID COMPOUNDS AND RELATED METHODS OF USE | MOORE II BOB M (US) | 2012-01-05 | — | — | US | disclosed |
| US-8022078-B2 | Pyrimidine classical cannabinoid compounds and related methods of use | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2011-09-20 | — | — | US | disclosed |
| US-20110046163-A1 | FURANOPYRIMIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2011-02-24 | — | — | US | disclosed |
| US-20090286815-A1 | Pyrimidine Classical Cannabinoid Compounds and Related Methods of Use | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286815-A1 | Pyrimidine Classical Cannabinoid Compounds and Related Methods of Use | CNR1, CNR2, GPR18 | BCL2 2803/4885BCL2L1 3225/4885CALM1 865/4885 |
| US-20110046163-A1 | FURANOPYRIMIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE | CNR1, CNR2, GPR17 | BCL2 1211/4885BCL2L1 1469/4885CALM1 534/4885 |
| US-20120004250-A1 | PYRIMIDINE CLASSICAL CANNABINOID COMPOUNDS AND RELATED METHODS OF USE | CNR1, CNR2, P2RX2 | BCL2 2115/4885BCL2L1 2670/4885CALM1 903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.