Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Pentobarbital. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.38 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | BCL9 | O00512 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pentobarbital SCHEMBL2293059 | 0.94 | LMNA (0.41) | LMNARECQLCYP3A4ALDH1A1KDM4E | |
| Pentobarbital SCHEMBL2288527 | 0.93 | LMNA (0.41) | LMNARECQLCYP3A4ALDH1A1KDM4E | |
| Pentobarbital SCHEMBL2291000 | 0.93 | LMNA (0.43) | LMNARECQLCYP3A4ALDH1A1KDM4E | |
| Pentobarbital SCHEMBL4202506 | 0.90 | LMNA (0.44) | LMNARECQLCYP3A4ALDH1A1KDM4E | |
| Pentobarbital SCHEMBL2401327 | 0.87 | LMNA (0.42) | LMNARECQLCYP3A4ALDH1A1KDM4E | |
| Pentobarbital SCHEMBL9680904 | 0.87 | LMNA (0.46) | LMNARECQLCYP3A4ALDH1A1KDM4E | |
| Pentobarbital SCHEMBL21523217 | 0.86 | RECQL (0.47) | LMNARECQLCYP3A4ALDH1A1KDM4E | |
| Pentobarbital SCHEMBL1451667 | 0.84 | CYP3A4 (0.53) | LMNARECQLCYP3A4ALDH1A1KDM4E | |
| Pentobarbital SCHEMBL8081141 | 0.83 | LMNA (0.47) | LMNARECQLCYP3A4ALDH1A1KDM4E | |
| Pentobarbital SCHEMBL1836479 | 0.83 | LMNA (0.49) | LMNARECQLCYP3A4ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490469-A2 | METHODS AND COMPOSITIONS FOR REMOVING RESIDUES AND SUBSTANCES FROM SUBSTRATES USING ENVIRONMENTALLY FRIENDLY SOLVENTS | North Carolina State University (US) | 2004-12-29 | — | — | EP | claimed |
| US-20030213747-A1 | Methods and compositions for removing residues and substances from substrates using environmentally friendly solvents | NORTH CAROLINA STATE UNIVERSITY | 2003-11-20 | — | — | US | claimed |
| WO-2003072215-A2 | METHODS AND COMPOSITIONS FOR REMOVING RESIDUES AND SUBSTANCES FROM SUBSTRATES USING ENVIRONMENTALLY FRIENDLY SOLVENTS | NORTH CAROLINA STATE UNIVERSITY (US) | 2003-09-04 | — | — | WO | claimed |
| US-11732223-B2 | Solvent compositions for removing petroleum residue from a substrate and methods of use thereof | Crude Spill Cleaning Co. Inc (US) | 2023-08-22 | — | — | US | disclosed |
| US-11001789-B2 | Solvent compositions for removing petroleum residue from a substrate and methods of use thereof | Crude Spill Cleaning Co. Inc. (US) | 2021-05-11 | — | — | US | disclosed |
| US-20180037850-A1 | Solvent compositions for removing petroleum residue from a substrate and methods of use thereof | CRUDE SPILL CLEANING COMPANY, INC. | 2018-02-08 | — | — | US | disclosed |
| US-20150152363-A1 | Solvent compositions for removing petroleum residue from a substrate and methods of use thereof | TROXLER ELECTRONIC LABORATORIES, INC. | 2015-06-04 | — | — | US | disclosed |
| US-8951951-B2 | Solvent compositions for removing petroleum residue from a substrate and methods of use thereof | TROXLER ELECTRONIC LABORATORIES, INC. (US) | 2015-02-10 | — | — | US | disclosed |
| US-8951952-B2 | Solvent compositions for removing petroleum residue from a substrate and methods of use thereof | TROXLER ELECTRONIC LABORATORIES, INC. (US) | 2015-02-10 | — | — | US | disclosed |
| US-20130133694-A1 | SOLVENT COMPOSITIONS FOR REMOVING PETROLEUM RESIDUE FROM A SUBSTRATE AND METHODS OF USE THEREOF | TROXLER ELECTRONICS LABORATORIES, INC. (US) | 2013-05-30 | — | — | US | disclosed |
| US-20120264671-A1 | METHODS AND COMPOSITIONS FOR REMOVING RESIDUES AND SUBSTANCES FROM SUBSTRATES USING ENVIRONMENTALLY FRIENDLY SOLVENTS | CARBONELL RUBEN G (US) | 2012-10-18 | — | — | US | disclosed |
| US-7465395-B2 | Methods and compositions for removing residues and substances from substrates using environmentally friendly solvents | NORTH CAROLINA STATE UNIVERSITY (US) | 2008-12-16 | — | — | US | disclosed |
| EP-1723224-A4 | SOLVENT COMPOSITIONS FOR REMOVING PETROLEUM RESIDUE FROM A SUBSTRATE AND METHODS OF USE THEREOF | TROXLER ELECTRONICS LAB INC (US) | 2008-02-27 | — | — | EP | disclosed |
| US-20070095753-A1 | Methods and compositions for removing residues and substances from substrates using environmentally friendly solvents | CARBONELL RUBEN G | 2007-05-03 | — | — | US | disclosed |
| EP-1723224-A2 | SOLVENT COMPOSITIONS FOR REMOVING PETROLEUM RESIDUE FROM A SUBSTRATE AND METHODS OF USE THEREOF | Troxler Electronics Laboratories, Inc. (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005091771-A2 | SOLVENT COMPOSITIONS FOR REMOVING PETROLEUM RESIDUE FROM A SUBSTRATE AND METHODS OF USE THEREOF | TROXLER ELECTRONICS LABORATORIES, INC. (US) | 2005-10-06 | — | — | WO | disclosed |
| US-20050197267-A1 | 10-60% by weight aromatic ester, 30-60% by weight aliphatic ester, 0-15% by weight co-solvent, 0-10% by weight cyclic terpene or terpenoid, 0-1% by weight odor-masking agent and 0-20% by weight nonionic surfactant; for removing petroleum residues (e.g., asphalt) from work surface such as truck bed | TROXLER ELECTRONICS LABORATORIES, INC. (US) | 2005-09-08 | — | — | US | disclosed |
| EP-1490469-A2 | METHODS AND COMPOSITIONS FOR REMOVING RESIDUES AND SUBSTANCES FROM SUBSTRATES USING ENVIRONMENTALLY FRIENDLY SOLVENTS | North Carolina State University (US) | 2004-12-29 | — | — | EP | disclosed |
| US-20030213747-A1 | Methods and compositions for removing residues and substances from substrates using environmentally friendly solvents | NORTH CAROLINA STATE UNIVERSITY | 2003-11-20 | — | — | US | disclosed |
| WO-2003072215-A2 | METHODS AND COMPOSITIONS FOR REMOVING RESIDUES AND SUBSTANCES FROM SUBSTRATES USING ENVIRONMENTALLY FRIENDLY SOLVENTS | NORTH CAROLINA STATE UNIVERSITY (US) | 2003-09-04 | — | — | WO | disclosed |