Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Pentobarbital. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.45 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.45 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pentobarbital SCHEMBL3727386 | 0.94 | CYP3A4 (0.48) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| Pentobarbital SCHEMBL7261796 | 0.92 | CYP3A4 (0.44) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| Pentobarbital SCHEMBL1451667 | 0.92 | CYP3A4 (0.53) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| Pentobarbital SCHEMBL6822766 | 0.91 | LMNA (0.51) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| Pentobarbital SCHEMBL15659234 | 0.89 | LMNA (0.50) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| Pentobarbital SCHEMBL2126265 | 0.89 | LMNA (0.49) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| Pentobarbital SCHEMBL8081141 | 0.89 | LMNA (0.47) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| Pentobarbital SCHEMBL4907433 | 0.88 | LMNA (0.49) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| Pentobarbital SCHEMBL2769858 | 0.88 | CYP3A4 (0.51) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| Pentobarbital SCHEMBL15533339 | 0.88 | LMNA (0.46) | LMNACYP3A4KDM4EALDH1A1GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 184 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107793650-A | The formed article for manufacturing the method for rubber composition and being formed by the rubber composition | 普尔曼公司 | 2018-03-13 | — | — | CN | claimed |
| CN-1896871-B | Alkali development resin composition | ADEKA CORP | 2013-06-12 | — | — | CN | claimed |
| CN-101006393-B | Alkali development-type photosensitive resin composition, substrate with protrusions for liquid crystal split orientational control and color filter formed using the same, and liquid crystal display device | TOPPAN PRINTING CO.,LTD. (JP) | 2011-11-30 | — | — | CN | claimed |
| US-7396895-B2 | Branched polyarylene ethers and processes for the preparation thereof | XEROX CORPORATION (US) | 2008-07-08 | — | — | US | claimed |
| US-7067608-B2 | Process for preparing branched polyarylene ethers | XEROX CORPORATION (US) | 2006-06-27 | — | — | US | claimed |
| US-20050208416-A1 | Branched polyarylene ethers and processes for the preparation thereof | XEROX CORPORATION | 2005-09-22 | — | — | US | claimed |
| US-20050154178-A1 | Process for preparing branched polyarylene ethers | XEROX CORPORATION | 2005-07-14 | — | — | US | claimed |
| US-5342746-A | Pyrazolo-azole couplers with coupler solvent of long chain unsaturated alcohol | EASTMAN KODAK COMPANY (US) | 1994-08-30 | — | — | US | claimed |
| EP-0550359-A1 | Method for the formation of color photographic materials with high coupling reactivity and reduced color developer pH sensitivity | EASTMAN KODAK COMPANY (US) | 1993-07-07 | — | — | EP | claimed |
| US-12509433-B2 | Process for the production of furfural using a water immiscible organic solvent | Covation Inc. (US) | 2025-12-30 | — | — | US | disclosed |
| CN-117715990-A | Fluorine-free surfactant and foam composition | 罗伯特·瓦伦丁·卡索斯基 | 2024-03-15 | — | — | CN | disclosed |
| EP-3703140-B1 | METHOD FOR MANUFACTURING THERMOELECTRIC CONVERSION MODULE, THERMOELECTRIC CONVERSION MODULE, AND BINDER FOR THERMOELECTRIC CONVERSION MODULE | RESONAC CORP (JP) | 2023-11-22 | — | — | EP | disclosed |
| EP-3569329-B1 | COPPER PASTE FOR PRESSURELESS BONDING, BONDED BODY AND SEMICONDUCTOR DEVICE | RESONAC CORP (JP) | 2023-11-01 | — | — | EP | disclosed |
| US-11787773-B2 | Process for the production of furfural | SHELL USA, INC. (US) | 2023-10-17 | — | — | US | disclosed |
| WO-1986005492-A1 | METAL SALTS OF HYDROCARBYL SUBSTITUTED AROMATIC PHOSPHORODITHIOIC ACIDS | THE LUBRIZOL CORPORATION (US) | 1986-09-25 | — | — | WO | disclosed |
| US-4518038-A | ENHANCED OIL RECOVERY SURFACTANTS | TEXACO INC. (US) | 1985-05-21 | — | — | US | disclosed |
| US-4066707-A | METHOD FOR MANUFACTURE OF DIPHENOLS AND MONOALKYL ETHERS OF DIPHENOLS | AGENCY OF INDUSTRIAL SCIENCE & TECHNOLOGY (JA) | 1978-01-03 | — | — | US | disclosed |
| US-4044118-A | N-1-HALOMETHYL-1-S-DIALKYLPHOSPHOROTHIOATE METHINYL PHTHALIMIDE ON | TEXACO INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-3951832-A | COMPLEXED WITH ALKYL PHENOLS | TEXACO INC. (US) | 1976-04-20 | — | — | US | disclosed |
| US-3939272-A | 5,6-DIHYDRO-2-METHYL-1,4-OXATHIIN-3-CARBOXYANILIDE-4,4-DIOXIDE, ALKYLATED PHENOL | TEXACO INC. (US) | 1976-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12509433-B2 | Process for the production of furfural using a water immiscible organic solvent | SORD, PGD, HPD | GABRB3 4254/4885GABRA2 4252/4885GABRB2 4094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.