Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glyphosate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.32 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | BLM | P54132 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glyphosate SCHEMBL465980 | 0.92 | LMNA (0.34) | LMNABLMKMT2ATSHRMEN1 | |
| Glyphosate SCHEMBL612618 | 0.91 | GLRA1 (0.43) | LMNABLMKMT2ATSHRMEN1 | |
| Glyphosate SCHEMBL6056320 | 0.91 | MEN1 (0.40) | LMNABLMKMT2ATSHRMEN1 | |
| Glyphosate SCHEMBL29694166 | 0.91 | LMNA (0.43) | LMNABLMKMT2ATSHRMEN1 | |
| Glyphosate SCHEMBL1964442 | 0.91 | LMNA (0.43) | LMNABLMKMT2ATSHRMEN1 | |
| Glyphosate SCHEMBL30579951 | 0.91 | LMNA (0.43) | LMNABLMKMT2ATSHRMEN1 | |
| Glyphosate SCHEMBL16440 | 0.91 | LMNA (0.43) | LMNABLMKMT2ATSHRMEN1 | |
| Glyphosate SCHEMBL30579950 | 0.91 | LMNA (0.43) | LMNABLMKMT2ATSHRMEN1 | |
| Glyphosate SCHEMBL214438 | 0.91 | LMNA (0.43) | LMNABLMKMT2ATSHRMEN1 | |
| Glyphosate SCHEMBL8515704 | 0.91 | LMNA (0.43) | LMNABLMKMT2ATSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989392-B2 | Herbicidal compositions containing glyphosate bipyridilium | MONSANTO TECHNOLOGY, LLC (US) | 2011-08-02 | — | — | US | claimed |
| EP-1343375-B1 | AQUEOUS PESTICIDE FORMULATIONS AND NOVEL SURFACTANTS | MONSANTO TECHNOLOGY LLC (US) | 2006-08-02 | — | — | EP | claimed |
| US-20060148648-A1 | Herbicidal compositions containing glyphosate bipyridilium | MONSANTO TECHNOLOGY LLC | 2006-07-06 | — | — | US | claimed |
| US-7049270-B2 | Potassium glyphosate formulations | MONSANTO TECHNOLOGY LLC (US) | 2006-05-23 | — | — | US | claimed |
| EP-1343375-A2 | AQUEOUS PESTICIDE FORMULATIONS AND NOVEL SURFACTANTS | Monsanto Technology LLC (US) | 2003-09-17 | — | — | EP | claimed |
| US-20030104943-A1 | Novel surfactants and formulations | MONSANTO TECHNOLOGY LLC | 2003-06-05 | — | — | US | claimed |
| WO-2002021924-A2 | HERBICIDAL COMPOSITIONS CONTAINING GLYPHOSATE AND BIPYRIDILIUM | MONSANTO TECHNOLOGY LLC (US) | 2002-03-21 | — | — | WO | claimed |
| WO-2001089302-A2 | AQUEOUS PESTICIDE FORMULATIONS AND NOVEL SURFACTANTS | MONSANTO TECHNOLOGY, LLC (US) | 2001-11-29 | — | — | WO | claimed |
| US-20060265780-A1 | Interaction of glyphosate with photosystem II inhibitor herbicides as a selection tool for roundup ready events | MONSANTO TECHNOLOGY LLC (US) | 2006-11-23 | — | — | US | disclosed |
| WO-2002012165-A1 | (POLY)ETHEREAL AMMONIUM SALTS OF HERBICIDES BEARING ACIDIC MOIETIES AND THEIR USE AS HERBICIDES | ISHIHARA SANGYO KAISHA , LTD. (JP) | 2002-02-14 | — | — | WO | disclosed |
| US-6300323-B1 | ACIDIC HERBICIDES | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2001-10-09 | — | — | US | disclosed |
| US-4159901-A | AMINOMETHYLENEPHOSPHONIC ACID, THIOL | MONSANTO COMPANY (US) | 1979-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148648-A1 | Herbicidal compositions containing glyphosate bipyridilium | SYMPK, PTMS, GLO1 | PDE4D 1836/4885PDE3A 948/4885LMNA 3280/4885 |
| US-20030104943-A1 | Novel surfactants and formulations | PHOSPHO1, GNMT, DDT | PDE4D 747/4885PDE3A 854/4885LMNA 1966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.