Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.65 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.65 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.65 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2126609 | 0.86 | RAB9A (0.69) | CASP3SENP7SENP6SENP8ALDH1A1 | |
| SCHEMBL29882661 | 0.85 | ALDH1A1 (0.65) | CASP3SENP7SENP6SENP8ALDH1A1 | |
| SCHEMBL1691257 | 0.83 | RAB9A (0.73) | CASP3SENP7SENP6SENP8ALDH1A1 | |
| SCHEMBL4726717 | 0.80 | ALDH1A1 (0.68) | ALDH1A1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6391407 | 0.79 | CASP3 (1.00) | CASP3SENP7SENP6SENP8ALDH1A1 | |
| SCHEMBL2129500 | 0.78 | RAB9A (0.58) | CASP3SENP7SENP6SENP8ALDH1A1 | |
| SCHEMBL11407545 | 0.75 | RAB9A (0.76) | CASP3SENP7SENP6SENP8ALDH1A1 | |
| SCHEMBL16568913 | 0.75 | ALDH1A1 (0.57) | ALDH1A1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7275462 | 0.74 | TP53 (0.80) | ALDH1A1MAPTSMN1; SMN2KDM4EKEAP1 | |
| SCHEMBL3765312 | 0.73 | TP53 (0.67) | MAPTRAB9ASMN1; SMN2NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220274980-A1 | PHARMACOLOGICAL INHIBITORS OF THE ENL YEATS DOMAIN | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-09-01 | — | — | US | disclosed |
| WO-2021021904-A1 | PHARMACOLOGICAL INHIBITORS OF THE ENL YEATS DOMAIN | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220274980-A1 | PHARMACOLOGICAL INHIBITORS OF THE ENL YEATS DOMAIN | YEATS2, MLLT1, YEATS4 | CASP3 2933/4885SENP7 2162/4885SENP6 1774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.