SCHEMBL22947700

SCHEMBL22947700

C[Si]1(C)c2ccccc2-c2ccc(-c3ccccc3Cl)cc21

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.44
PDK2 Q15119 1/20 0.41
TNKS2 Q9H2K2 1/20 0.40
BACE1 P56817 1/20 0.40
TRPA1 O75762 1/20 0.40
RORA P35398 1/20 0.39
RORC P51449 1/20 0.39
JAK2 O60674 1/20 0.39
JAK1 P23458 1/20 0.39
TYK2 P29597 1/20 0.39
JAK3 P52333 1/20 0.39
AR P10275 1/20 0.38
PGR P06401 2/20 0.38
MAOB P27338 2/20 0.38
ALOX5AP P20292 1/20 0.38
FEN1 P39748 1/20 0.38
HSD11B1 P28845 1/20 0.36
AOC3 Q16853 1/20 0.35
PAK1 Q13153 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27392408 0.90 RORA (0.45) CYP2A6PDK2TNKS2BACE1TRPA1
SCHEMBL22947541 0.83 CYP1A2 (0.42) PDK2RORARORCMAOB
SCHEMBL22947476 0.81 CYP2A6 (0.43) CYP2A6PDK2TNKS2BACE1TRPA1
SCHEMBL27394478 0.80 PDK2 (0.43) PDK2RORARORCPGRMAOB
SCHEMBL27383242 0.79 ALDH1A1 (0.44) RORARORCMAOB
SCHEMBL27394818 0.79 RORA (0.34) RORARORC
SCHEMBL25818451 0.79 S100A4 (0.39) RORARORC
SCHEMBL27394693 0.78 RXRA (0.40) PDK2RORARORCPGR
SCHEMBL31267454 0.78 RORA (0.42) CYP2A6PDK2RORARORCHSD11B1
SCHEMBL17068902 0.78 RORA (0.42) CYP2A6PDK2RORARORCHSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024106877-A1 COMPOUND FOR ORGANIC ELECTRICAL ELEMENT, ORGANIC ELECTRICAL ELEMENT USING SAME, AND ELECTRONIC DEVICE THEREOF 덕산네오룩스 주식회사 2024-05-23 WO disclosed
US-20210036245-A1 HETEROAROMATIC COMPOUNDS MERCK PATENT GMBH (DE) 2021-02-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210036245-A1 HETEROAROMATIC COMPOUNDS ETV6, FES, LEF1 CYP2A6 1117/4885PDK2 1353/4885TNKS2 4214/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.