Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.52 |
| ▸ | CTRL | P40313 | 1/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 8/20 | 0.52 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.52 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.52 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.52 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.52 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.52 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.52 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.52 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.52 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.52 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.52 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.52 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.52 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11927495 | 0.94 | OPRK1 (0.55) | PSMB5PSMB9CYP3A4CYP3A5CYP3A7 | |
| SCHEMBL21886575 | 0.90 | OPRK1 (0.51) | TMPRSS11DCTRLPSMB5PSMB9CYP3A4 | |
| SCHEMBL18413052 | 0.88 | OPRK1 (0.57) | PSMB5PSMB9CYP3A4CYP3A5CYP3A7 | |
| SCHEMBL24360679 | 0.87 | OPRK1 (0.62) | TMPRSS11DCTRLPSMB5PSMB9CYP3A4 | |
| SCHEMBL11927496 | 0.87 | OPRK1 (0.60) | OPRK1 | |
| SCHEMBL21886313 | 0.86 | OPRK1 (0.66) | TMPRSS11DCTRLPSMB5PSMB9CYP3A4 | |
| SCHEMBL11927490 | 0.86 | REN (0.49) | PSMB5PSMB8OPRK1CTSS | |
| SCHEMBL13290902 | 0.86 | OPRK1 (0.59) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| SCHEMBL24360600 | 0.86 | OPRK1 (0.63) | TMPRSS11DCTRLPSMB5PSMB9CYP3A4 | |
| SCHEMBL24001142 | 0.86 | OPRK1 (0.65) | TMPRSS11DCTRLPSMB5PSMB9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11684674-B2 | Oral formulations of kappa opioid receptor agonists | CARA THERAPEUTICS, INC. (US) | 2023-06-27 | — | — | US | disclosed |
| US-20210346505-A1 | Oral Formulations of Kappa Opioid Receptor Agonists | CARA THERAPEUTICS, INC. | 2021-11-11 | — | — | US | disclosed |
| US-10913769-B2 | Synthetic peptide amides and dimers thereof | CARA THERAPEUTICS, INC. (US) | 2021-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210346505-A1 | Oral Formulations of Kappa Opioid Receptor Agonists | OPRK1, OPRL1, OGFR | TMPRSS11D 2519/4885CTRL 4469/4885PSMB5 2240/4885 |
| US-10913769-B2 | Synthetic peptide amides and dimers thereof | OPRK1, OPRL1, OPRM1 | TMPRSS11D 745/4885CTRL 394/4885PSMB5 992/4885 |
| US-11684674-B2 | Oral formulations of kappa opioid receptor agonists | OPRK1, OPRL1, OGFR | TMPRSS11D 2519/4885CTRL 4469/4885PSMB5 2240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.