Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MRE11 | P49959 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9872609 | 0.99 | ITGB3 (0.53) | ITGB3ITGA2BSIGMAR1HTR4SIRT2 | |
| SCHEMBL8384876 | 0.95 | SIGMAR1 (0.56) | ITGB3ITGA2BSIGMAR1HTR4SIRT2 | |
| SCHEMBL6605317 | 0.89 | SIGMAR1 (0.51) | ITGB3ITGA2BSIGMAR1ALDH1A1L3MBTL1 | |
| SCHEMBL6620815 | 0.87 | KDM4E (0.58) | SIGMAR1HTR4ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL28379360 | 0.85 | GAA (0.44) | ITGB3ITGA2BSIGMAR1HTR4ALDH1A1 | |
| SCHEMBL12869919 | 0.85 | KDM4E (0.60) | SIGMAR1ALDH1A1KDM4EL3MBTL1NPC1 | |
| SCHEMBL11114519 | 0.85 | HTR4 (0.47) | SIGMAR1HTR4ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL6382314 | 0.82 | KDM4E (0.58) | ITGB3ITGA2BSIGMAR1HTR4ALDH1A1 | |
| SCHEMBL25134221 | 0.82 | EGFR (0.50) | ITGB3ITGA2BSIGMAR1ALDH1A1L3MBTL1 | |
| SCHEMBL6621341 | 0.81 | SMN1; SMN2 (0.59) | ITGB3ITGA2BSIGMAR1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11771697-B2 | Small molecule degraders of polybromo-1 (PBRM1) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-10-03 | — | — | US | disclosed |
| US-11771697-B2 | Small molecule degraders of polybromo-1 (PBRM1) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-10-03 | — | — | US | disclosed |
| EP-3787747-A1 | SMALL MOLECULE DEGRADERS OF POLYBROMO-1 (PBRM1) | Dana-Farber Cancer Institute, Inc. (US) | 2021-03-10 | — | — | EP | disclosed |
| US-20210038599-A1 | SMALL MOLECULE DEGRADERS OF POLYBROMO-1 (PBRM1) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-02-11 | — | — | US | disclosed |
| US-20210038599-A1 | SMALL MOLECULE DEGRADERS OF POLYBROMO-1 (PBRM1) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11771697-B2 | Small molecule degraders of polybromo-1 (PBRM1) | PBRM1, SMARCC1, SMARCC2 | ITGB3 4091/4885ITGA2B 3857/4885SIGMAR1 2181/4885 |
| US-20210038599-A1 | SMALL MOLECULE DEGRADERS OF POLYBROMO-1 (PBRM1) | PBRM1, SMARCC1, SMARCC2 | ITGB3 4091/4885ITGA2B 3857/4885SIGMAR1 2181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.