Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | HRH2 | P25021 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8384876 | 0.92 | SIGMAR1 (0.56) | SIGMAR1ALDH1A1MAPK1L3MBTL1ITGB3 | |
| SCHEMBL22959810 | 0.89 | ITGB3 (0.54) | SIGMAR1ALDH1A1MAPK1L3MBTL1ITGB3 | |
| SCHEMBL9872609 | 0.88 | ITGB3 (0.53) | SIGMAR1ALDH1A1MAPK1L3MBTL1ITGB3 | |
| SCHEMBL11128528 | 0.87 | EGFR (0.58) | SIGMAR1ALDH1A1MAPK1L3MBTL1NOTUM | |
| SCHEMBL25134221 | 0.86 | EGFR (0.50) | SIGMAR1ALDH1A1MAPK1L3MBTL1ITGB3 | |
| SCHEMBL6601404 | 0.85 | EGFR (0.54) | SIGMAR1ALDH1A1MAPK1L3MBTL1ITGB3 | |
| SCHEMBL12869921 | 0.85 | EGFR (0.60) | SIGMAR1ALDH1A1MAPK1L3MBTL1NOTUM | |
| Hydrochloric Acid SCHEMBL21814218 | 0.84 | EGFR (0.56) | SIGMAR1ALDH1A1MAPK1L3MBTL1ITGB3 | |
| SCHEMBL25421283 | 0.84 | EGFR (0.53) | SIGMAR1ALDH1A1MAPK1L3MBTL1ITGB3 | |
| SCHEMBL5059161 | 0.84 | EGFR (0.53) | SIGMAR1ALDH1A1MAPK1L3MBTL1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1204889-C | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2005-06-08 | — | — | CN | disclosed |
| EP-0741133-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2004-01-28 | — | — | EP | disclosed |
| US-6455529-B1 | OXAZOLIDIN-2-ONE DERIVATIVES; ANTICOAGULANTS; ANTIMETASTASIS, ANTICARCINOGENIC, ANTIISCHEMIC, AND ANTIINFLAMMATORY AGENTS; OSTEOPOROSIS, ARTERIOSCLEROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-09-24 | — | — | US | disclosed |
| EP-0697408-B1 | 1 substituted-phenyl-oxazolidene-2-one derivatives and their use as adhesion-receptor antagonists | MERCK PATENT GMBH (DE) | 2002-01-23 | — | — | EP | disclosed |
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| CN-1069640-C | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2001-08-15 | — | — | CN | disclosed |
| CN-1056141-C | Piperazine derivatives | MERCK PATENT GESELLSCHAFTR MIT (DE) | 2000-09-06 | — | — | CN | disclosed |
| CN-1052231-C | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2000-05-10 | — | — | CN | disclosed |
| EP-0623615-B1 | Substituted 1-phenyl-oxazolidin-2-one derivatives, their preparation and their use as adhesion-receptor antagonists | MERCK PATENT GMBH (DE) | 1999-06-30 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| US-5776937-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-07-07 | — | — | US | disclosed |
| US-5614535-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-03-25 | — | — | US | disclosed |
| EP-0741133-A2 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-11-06 | — | — | EP | disclosed |
| CN-1132201-A | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 1996-10-02 | — | — | CN | disclosed |
| CN-1125575-A | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 1996-07-03 | — | — | CN | disclosed |
| US-5532255-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-02 | — | — | US | disclosed |
| EP-0711770-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-15 | — | — | EP | disclosed |
| EP-0697408-A1 | 1 substituted-phenyl-oxazolidene-2-one derivatives and their use as adhesion-receptor antagonists | MERCK PATENT GmbH (DE) | 1996-02-21 | — | — | EP | disclosed |
| EP-0623615-A1 | Adhesion-receptor antagonists | MERCK PATENT GmbH (DE) | 1994-11-09 | — | — | EP | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |