Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7189439 | 0.73 | HDAC8 (0.34) | DAOHDAC8HDAC6 | |
| SCHEMBL1478216 | 0.70 | NPC1 (0.41) | DAO | |
| SCHEMBL3833537 | 0.68 | LMNA (0.48) | — | |
| SCHEMBL4491073 | 0.68 | ADRB1 (0.48) | — | |
| SCHEMBL30682551 | 0.68 | EIF2AK4 (0.33) | — | |
| SCHEMBL17967235 | 0.68 | PBK (0.43) | — | |
| SCHEMBL2280578 | 0.64 | BPTF (0.54) | BPTF | |
| SCHEMBL28935502 | 0.63 | CHRNA7 (0.52) | — | |
| SCHEMBL28583221 | 0.63 | CHRNB2 (0.38) | — | |
| SCHEMBL16353808 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999006-B2 | Anticancer agents; mitogen-activated protein kinases (MEK) | EXELIXIS, INC. (US) | 2011-08-16 | — | — | US | claimed |